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SYNTHESES OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES

SYNTHESES OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
不寻常的生物活性萜烯的合成
批准号:
3278722
负责人:
LEO A PAQUETTE
金额:
$16.66万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1983
资助国家:
美国
项目状态:
已结题
起止时间:
1983-04-01 至 1991-03-31

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中文摘要
翻译
提供了正在进行的合成努力应该达到顶峰的协议 在获得:(A)截胸素,一种产生的二萜抗生素 由几种担子菌产生;(B)倍半萜代谢物斯特普酸 );及(C) 3β-羟基-7-β-Kemp-8(9)-烯-6-酮,一种来自西红花的二萜 由初生白蚁士兵生产。此外,还概述了新的努力。 为了开发新的方法论,最终将 一种独特的双环化合物:(D)乙酰氧基奎尼特的实验室制备 小型棕色褐藻分泌的含环丙烷二萜;(E) 7,8-环氧基-4-碱基-6-酮,一种结构特殊的三环二萜 由某些类型的东方烟草生产;(F)马托菲酮,a 具有5/9/5-稠环骨架的三环三酮二萜, 对P-388(3PS)淋巴细胞具有良好的抑制活性 白血病检测系统;(G)乙酸新龙脑酯,一种不规则倍半萜 由太平洋软珊瑚Lemnalia africana生产;(H)Cerorubenic ACID-III,一种由Ceroplastes Rubens分泌的凯旋酮,因其 控制某些昆虫产卵行为的能力;及(I) 斑点菌素A,一种著名的粪便真菌斑点孔菌的产品 因为它的抗菌活性。
英文摘要
Protocols are offered by which ongoing synthetic efforts should culminate in the acquisition of: (a) pleuromutilin, a diterpene antibiotic produced by several basidiomycetes; (b) sterpuric acid, a sesquiterpenoid metabolite of the fungus Stereum purpureum; and (c) 3Beta-hydroxy-7Beta-kemp-8(9)-en-6-one, a cembrene-derived diterpene produced by nasute termite soldiers. In addition, new efforts are outlined for the purpose of developing new methodologies that will culminate in the laboratory preparation of: (d) acetoxycrenulide, a unique bicyclic cyclopropane-containing diterpenoid exuded by small brown phaeophyta; (e) 7,8-epoxy-4-basmen-6-one, a tricyclic diterpenoid of unusual structure produced by certain types of Oriental tobacco; (f) jatrophatrione, a tricyclic triketo diterpene possessing a 5/9/5-fused ring skeleton that exhibits good inhibitory activity toward the P-388 (3PS) lymphocytic leukemia test system; (g) neolemnanyl acetate, an irregular sesquiterpene produced by the Pacific soft coral Lemnalia africana; (h) cerorubenic acid-III, a kairomone secreted by Ceroplastes rubens recognized for its ability to control the ovipositional behavior of certain insects; and (i) punctatin A, a product of the dung fungus Poronia punctata that is reputed for its antibiotic activity.
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TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
  • 批准号:
    6416187
  • 项目类别:
  • 资助金额:
    $5.37万
  • 财政年份:
    2000
  • 负责人:
    LEO A PAQUETTE
  • 依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
  • 批准号:
    6559330
  • 项目类别:
  • 资助金额:
    $6.2万
  • 财政年份:
    2000
  • 负责人:
    LEO A PAQUETTE
  • 依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
  • 批准号:
    6027868
  • 项目类别:
  • 资助金额:
    $26.06万
  • 财政年份:
    2000
  • 负责人:
    LEO A PAQUETTE
  • 依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
  • 批准号:
    6350406
  • 项目类别:
  • 资助金额:
    $25.97万
  • 财政年份:
    2000
  • 负责人:
    LEO A PAQUETTE
  • 依托单位:
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