SYNTHESES OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
SYNTHESES OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
批准号:
3278722
负责人:
LEO A PAQUETTE
金额:
$16.66万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1983
资助国家:
美国
项目状态:
已结题
起止时间:
1983-04-01 至 1991-03-31
中文摘要
议定书提供了正在进行的综合努力应达到高潮
收购:(a)截短侧耳素,一种生产的二萜抗生素
(B)甾醇酸,一种倍半萜类代谢物
真菌Stereum purpureum;和(c)
3Beta-hydroxy-7Beta-kemp-8(9)-en-6-one,a cembrene-derived di萜烯
由纳苏特白蚁士兵制造。 此外,还概述了新的努力
为了开发新的方法,
实验室制备:(d)乙酰氧基克瑞舒利,一种独特双环
由小型棕色褐藻分泌的含环丙烷的二萜类化合物;(e)
7,8-环氧-4-巴斯曼-6-酮,一种结构奇特的三环二萜
由某些类型的东方烟草产生;(f)麻黄素,a
具有5/9/5-稠环骨架的三环三酮基二萜,
对P-388(3 PS)淋巴细胞具有良好的抑制活性
白血病测试系统;(g)乙酸新莱曼酯,一种不规则倍半萜
由太平洋软珊瑚Lemnalia africana产生;(h)蜡鲁本
酸-III,一种由红蜡蚧分泌的利它素,
控制某些昆虫产卵行为的能力;及(i)
punctatin A,粪菌Poronia punctata的产物,
因为它的抗生素活性。
英文摘要
Protocols are offered by which ongoing synthetic efforts should culminate
in the acquisition of: (a) pleuromutilin, a diterpene antibiotic produced
by several basidiomycetes; (b) sterpuric acid, a sesquiterpenoid metabolite
of the fungus Stereum purpureum; and (c)
3Beta-hydroxy-7Beta-kemp-8(9)-en-6-one, a cembrene-derived diterpene
produced by nasute termite soldiers. In addition, new efforts are outlined
for the purpose of developing new methodologies that will culminate in the
laboratory preparation of: (d) acetoxycrenulide, a unique bicyclic
cyclopropane-containing diterpenoid exuded by small brown phaeophyta; (e)
7,8-epoxy-4-basmen-6-one, a tricyclic diterpenoid of unusual structure
produced by certain types of Oriental tobacco; (f) jatrophatrione, a
tricyclic triketo diterpene possessing a 5/9/5-fused ring skeleton that
exhibits good inhibitory activity toward the P-388 (3PS) lymphocytic
leukemia test system; (g) neolemnanyl acetate, an irregular sesquiterpene
produced by the Pacific soft coral Lemnalia africana; (h) cerorubenic
acid-III, a kairomone secreted by Ceroplastes rubens recognized for its
ability to control the ovipositional behavior of certain insects; and (i)
punctatin A, a product of the dung fungus Poronia punctata that is reputed
for its antibiotic activity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:6416187
-
项目类别:
-
资助金额:$5.37万
-
财政年份:2000
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:6559330
-
项目类别:
-
资助金额:$6.2万
-
财政年份:2000
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:6350406
-
项目类别:
-
资助金额:$25.97万
-
财政年份:2000
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:6027868
-
项目类别:
-
资助金额:$26.06万
-
财政年份:2000
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:6551975
-
项目类别:
-
资助金额:$1.75万
-
财政年份:2000
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:6497941
-
项目类别:
-
资助金额:$26.8万
-
财政年份:2000
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:6628425
-
项目类别:
-
资助金额:$27.64万
-
财政年份:2000
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:2105131
-
项目类别:
-
资助金额:$24.13万
-
财政年份:1995
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:2008491
-
项目类别:
-
资助金额:$25.17万
-
财政年份:1995
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:2105130
-
项目类别:
-
资助金额:$24.18万
-
财政年份:1995
-
负责人:LEO A PAQUETTE
-
依托单位:
TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
-
批准号:2405847
-
项目类别:
-
资助金额:$7.16万
-
财政年份:1995
-
负责人:LEO A PAQUETTE
-
依托单位:
MEDICINAL CHEMISTRY A STUDY SECTION
-
批准号:3555185
-
项目类别:
-
资助金额:$6.74万
-
财政年份:1986
-
负责人:LEO A PAQUETTE
-
依托单位:
SINGLE CRYSTAL X-RAY DIFFRACTION FACILITY
-
批准号:3519362
-
项目类别:
-
资助金额:$23.4万
-
财政年份:1986
-
负责人:LEO A PAQUETTE
-
依托单位:
MEDICINAL CHEMISTRY A STUDY SECTION
-
批准号:3555183
-
项目类别:
-
资助金额:$9.0万
-
财政年份:1986
-
负责人:LEO A PAQUETTE
-
依托单位:
SYNTHESIS OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
-
批准号:2175927
-
项目类别:
-
资助金额:$22.17万
-
财政年份:1983
-
负责人:LEO A PAQUETTE
-
依托单位:
SYNTHESIS OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
-
批准号:3278724
-
项目类别:
-
资助金额:$20.65万
-
财政年份:1983
-
负责人:LEO A PAQUETTE
-
依托单位:
SYNTHESES OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
-
批准号:3278721
-
项目类别:
-
资助金额:$16.0万
-
财政年份:1983
-
负责人:LEO A PAQUETTE
-
依托单位:
SYNTHESIS OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
-
批准号:3278719
-
项目类别:
-
资助金额:$15.83万
-
财政年份:1983
-
负责人:LEO A PAQUETTE
-
依托单位:
SYNTHESES OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
-
批准号:3278723
-
项目类别:
-
资助金额:$17.7万
-
财政年份:1983
-
负责人:LEO A PAQUETTE
-
依托单位:
SYNTHESIS OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES
-
批准号:3278725
-
项目类别:
-
资助金额:$21.44万
-
财政年份:1983
-
负责人:LEO A PAQUETTE
-
依托单位:
海外基金