GENETIC ANALYSIS OF PROTEIN TRANSPORT INTO MITOCHONDRIA
GENETIC ANALYSIS OF PROTEIN TRANSPORT INTO MITOCHONDRIA
批准号:
3283776
负责人:
Elton T. YOUNG
金额:
$18.3万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-07-01 至 1993-06-30
关键词:
Saccharomyces aerobiosis alcohol dehydrogenase circular dichroism drug resistance fermentation fungal genetics genetic manipulation genetic mapping genetic recombination isozymes lethal genes membrane proteins microorganism metabolism mitochondria molecular cloning mutant nuclear magnetic resonance spectroscopy nucleic acid sequence protein sequence protein signal sequence protein transport receptor
中文摘要
信号序列在蛋白质靶向其上的作用
细胞内的定位将通过遗传、生化和
重组DNA方法。通过使用酵母,我们可以
采用遗传学的方法来识别结构的两个元素
领导者本身,以及它与之相连的蜂窝组件
互动。变种人将被隔离,因为他们不能
正确定位在细胞质中合成的蛋白质并
注定是线粒体,或者是由于无法生存
与蛋白质靶向的缺陷有关。合成纤维的结构
线粒体的靶向序列将由两个-
三维核磁共振光谱学。突变型
对进口有缺陷或卵裂有缺陷的前测序进行研究
将结构的变化与功能的变化联系起来。
合成的前序列也将被用作探测器,试图
识别线粒体上作为受体的蛋白质
将蛋白质定位到细胞器。
英文摘要
The role of the signal sequence in targeting a protein to its
intracellular location will be studied by genetic, biochemical, and
recombinant DNA methods. By using the yeast Saccharomyces we can
take a genetic approach to identifying both elements of structure
of the leader itself, and the cellular components with which it
interacts. Mutants will be isolated by virtue of being unable to
correctly localize a protein synthesized in the cytoplasm and
destined for the mitochondria, or by virtue of being inviable due
to a defect in protein targeting. The structure of a synthetic
mitochondrial targeting sequence will be determined by two-
dimensional nuclear magnetic resonance spectroscopy. Mutant
presequences, defective in import or cleavage will be studied to
correlate alterations in structure with alterations in function.
The synthetic presequence will also be used as a probe to try to
identify proteins on the mitochondria that act as receptor for
targeting proteins to that organelle.
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