20-BBSRC/NSF-BIO Regulatory control of innate immune response in marine invertebrates
20-BBSRC/NSF-BIO 海洋无脊椎动物先天免疫反应的调节控制
基本信息
- 批准号:BB/W017865/1
- 负责人:
- 金额:$ 65.39万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Animals live in constantly changing environments that are rich in microbial life. Immune systems orchestrate the complex, dynamic relationships between animals and microbes by both eliminating pathogenic microbes as well as promoting the growth of beneficial microbiota. However, our understanding of innate immune mechanisms in most animal phyla, including vertebrates, remains limited. The proposed research addresses this considerable knowledge gap by exploiting the experimental advantages of echinoderm larvae to investigate immune responses in a relatively unexplored animal lineage. Echinoderm larvae are morphologically simple, free-swimming multicellular organisms equipped with a sophisticated cellular and molecular immune system. By integrating recently available sequencing data from several echinoderm species with technology for measuring gene expression at single-cell resolution, the proposed research will significantly advance our understanding of animal immunity. This proposal describes a collaborative, systems-level approach to define the regulatory mechanisms that control immune responses across different echinoderm species. This innovative analysis will reveal evolutionarily conserved principles of immune response as well as species-specific adaptations.
动物生活在不断变化的环境中,这些环境富含微生物。免疫系统通过消除病原微生物以及促进有益微生物群的生长来协调动物和微生物之间复杂的动态关系。然而,我们对包括脊椎动物在内的大多数动物门的先天免疫机制的理解仍然有限。拟议的研究通过利用棘皮动物幼虫的实验优势来研究相对未开发的动物谱系中的免疫反应,解决了这一相当大的知识差距。棘皮动物的幼虫是形态简单、自由游动的多细胞生物,具有复杂的细胞和分子免疫系统。通过将最近获得的几种棘皮动物的测序数据与以单细胞分辨率测量基因表达的技术相结合,拟议的研究将大大提高我们对动物免疫的理解。该提案描述了一种协作的系统级方法来定义控制不同棘皮动物物种免疫反应的调节机制。这种创新的分析将揭示免疫反应的进化保守原则以及物种特异性适应。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paola Oliveri其他文献
Homeobox-containing gene transiently expressed in a spatially restricted pattern in the early sea urchin embryo.
含有同源盒的基因在早期海胆胚胎中以空间受限的模式短暂表达。
- DOI:
10.1073/pnas.92.18.8180 - 发表时间:
1995 - 期刊:
- 影响因子:11.1
- 作者:
M. D. Bernardo;Roberta Russo;Paola Oliveri;R. Melfi;Giovanni Spinelli - 通讯作者:
Giovanni Spinelli
Gata and bHLH factors form a conserved regulatory circuit for deuterostome immunocyte development
- DOI:
10.1016/j.ydbio.2010.05.408 - 发表时间:
2010-08-01 - 期刊:
- 影响因子:
- 作者:
Cynthia Messier-Solek;Paola Oliveri;Jonathan P. Rast - 通讯作者:
Jonathan P. Rast
Molecular characterization of the apical organ of the anthozoan <em>Nematostella vectensis</em>
- DOI:
10.1016/j.ydbio.2014.11.019 - 发表时间:
2015-02-01 - 期刊:
- 影响因子:
- 作者:
Chiara Sinigaglia;Henriette Busengdal;Avi Lerner;Paola Oliveri;Fabian Rentzsch - 通讯作者:
Fabian Rentzsch
Paola Oliveri的其他文献
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{{ truncateString('Paola Oliveri', 18)}}的其他基金
Discovering missing links in neuropeptide evolution and function
发现神经肽进化和功能中缺失的环节
- 批准号:
BB/X001806/1 - 财政年份:2024
- 资助金额:
$ 65.39万 - 项目类别:
Research Grant
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