20-BBSRC/NSF-BIO Regulatory control of innate immune response in marine invertebrates

20-BBSRC/NSF-BIO 海洋无脊椎动物先天免疫反应的调节控制

• 批准号: BB/W017865/1
• 负责人: Paola Oliveri
• 金额: $ 65.39万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW017865%2F1
• 关键词: 20; BBSRC; NSF; BIO; Regulatory

Animals live in constantly changing environments that are rich in microbial life. Immune systems orchestrate the complex, dynamic relationships between animals and microbes by both eliminating pathogenic microbes as well as promoting the growth of beneficial microbiota. However, our understanding of innate immune mechanisms in most animal phyla, including vertebrates, remains limited. The proposed research addresses this considerable knowledge gap by exploiting the experimental advantages of echinoderm larvae to investigate immune responses in a relatively unexplored animal lineage. Echinoderm larvae are morphologically simple, free-swimming multicellular organisms equipped with a sophisticated cellular and molecular immune system. By integrating recently available sequencing data from several echinoderm species with technology for measuring gene expression at single-cell resolution, the proposed research will significantly advance our understanding of animal immunity. This proposal describes a collaborative, systems-level approach to define the regulatory mechanisms that control immune responses across different echinoderm species. This innovative analysis will reveal evolutionarily conserved principles of immune response as well as species-specific adaptations.

动物生活在不断变化的环境中，这些环境富含微生物寿命。免疫系统通过消除致病性微生物以及促进有益微生物群的生长来策划动物与微生物之间的复杂，动态关系。但是，我们对包括脊椎动物在内的大多数动物门中先天免疫机制的理解仍然有限。提出的研究通过利用棘皮动物幼虫的实验优势来研究相对未开发的动物谱系中的免疫反应，以解决这一大量知识差距。棘皮动物幼虫在形态上是简单的，自由磁火的多细胞生物，配备了复杂的细胞和分子免疫系统。通过将来自几种棘皮动物物种的最近可用的测序数据与用于测量单细胞分辨率的基因表达的技术，该研究将大大提高我们对动物免疫力的理解。该提案描述了一种协作，系统级别的方法，以定义控制不同棘皮动物物种的免疫反应的调节机制。这种创新的分析将揭示免疫反应的进化保守原理以及物种特异性的适应。