Ageing Research Translation (ART) of Healthy Ageing Network

健康老龄化网络的老龄化研究翻译（ART）

• 批准号: BB/W018209/1
• 负责人: Miles Witham
• 金额: $ 39.66万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW018209%2F1
• 关键词: Ageing; Research; Translation; ART; Healthy

The global population is ageing - more people are living longer lives and a greater proportion of the population are aged 65 and over than at any time in the past. This is clearly good news, however improvements in healthspan (that is, the number of years people spend in good health, living independently) have not kept pace with improvements in lifespan (the number of years people live for). This means that the additional years of life are not always lived in good health.To address this, the UK government has set the ambitious target of ensuring that people can enjoy at least five additional healthy, independent years of life by 2035. However, a recent House of Lords Science and Technology Committee report on healthy ageing has concluded that this target is unlikely to be met unless we develop new ways to research ageing that lead to the identification of effective methods to promote healthy ageing across life. In particular, the House of Lords committee noted the need to join up different areas of ageing research to make sure that discoveries in the laboratory are followed up by studies in people.The aim of the Ageing Research Translation (ART) of Healthy Ageing Network is to address this scientific challenge. Our Network will create links between laboratory research, detailed studies in humans, and existing sets of information on health, illness and lifestyle. We will combine these areas of expertise to build a unique Translational Platform (a series of studies with standardised protocols, shared recruitment methods and shared outcome measures) for Healthy Ageing across the Life Course to test ways to improve people's health and wellbeing from birth to old age. To achieve this vision, the Network will bring together researchers from different academic disciplines across the UK and beyond, including people with expertise in the biology of ageing, epidemiology, patient care, physiology, clinical research studies including trials, mathematics, statistics and data science along with members of the public and representatives from charities, policymakers and industry.Through their involvement in the Network and the wide range of activities organised, members will be supported to work together to find new ways to study underlying biological processes of ageing in humans and, to use the evidence generated from this research to develop and test interventions that promote healthy ageing. We will hold a series of stakeholder meetings and conferences to bring people together to form new links and share knowledge. Importantly, we will nurture the careers of new researchers. The ART of Healthy Ageing Network will provide the training and opportunities that they need to build successful careers in translational ageing research and work successfully with a broad range of colleagues. Finally, the ART of Healthy Ageing Network will promote opportunities for closer working through a series of pilot projects, enabling different groups of researchers to start solving problems and overcoming technical, ethical and organisational barriers to make sure that we can build this UK-wide platform to conduct ageing studies in humans.The activities of the ART of Healthy Ageing Network will deliver a growing interdisciplinary network of researchers, a thriving community of early career researchers with interdisciplinary training, a broad and engaged stakeholder community, a clear road map for growing the Network and developing UK infrastructure, and projects showing initial proof-of-concept for our Translational Platform for Healthy Ageing across the Life Course. It will generate new collaborations between researchers with the critical mass necessary to develop credible applications for further funding. By delivering additional funding and hence capacity to do more research, our ART of Healthy Ageing Network will accelerate translational Ageing research in the UK and internationally to deliver the goal of improving healthspan for all.

全球人口正在老龄化--越来越多的人寿命更长，65岁及以上人口的比例比过去任何时候都要大。这显然是个好消息，然而，健康寿命(即人们健康、独立生活的年数)的改善并没有跟上寿命(人们的寿命)的改善。这意味着额外的寿命并不总是健康的。为了解决这一问题，英国政府制定了雄心勃勃的目标，确保到2035年，人们可以享受至少五年的健康、独立的寿命。然而，最近上议院科学和技术委员会关于健康老龄化的一份报告得出结论，除非我们开发研究老龄化的新方法，从而确定促进终身健康老龄化的有效方法，否则这一目标不太可能实现。上议院委员会特别指出，需要将老龄化研究的不同领域结合起来，以确保实验室中的发现得到人体研究的跟进。健康老龄化网络的老龄化研究翻译(ART)旨在应对这一科学挑战。我们的网络将在实验室研究、人体详细研究和现有的关于健康、疾病和生活方式的信息之间建立联系。我们将结合这些专业领域，建立一个独特的翻译平台(一系列研究，采用标准化的方案、共享的招募方法和共享的结果衡量标准)，以测试如何改善人们从出生到老年的健康和福祉。为了实现这一愿景，该网络将汇集来自英国国内外不同学科的研究人员，包括具有衰老生物学、流行病学、患者护理、生理学、临床研究研究(包括试验、数学、统计学和数据科学)的专业知识的人，以及公众和来自慈善机构、政策制定者和行业的代表。通过参与该网络和组织的广泛活动，成员将得到支持，共同寻找研究人类衰老潜在生物过程的新方法，并利用这项研究产生的证据来开发和测试促进健康老龄化的干预措施。我们将举办一系列利益攸关方会议，将人们聚集在一起，形成新的联系，分享知识。重要的是，我们将培养新研究人员的职业生涯。健康老龄化网络的艺术将为他们提供所需的培训和机会，帮助他们在转化性老龄研究中建立成功的职业生涯，并与广泛的同事成功合作。最后，健康老龄化艺术网络将通过一系列试点项目促进更紧密的合作机会，使不同的研究人员群体能够开始解决问题，克服技术、道德和组织障碍，以确保我们能够建立这个全英国范围的平台，在人类中进行老龄化研究。健康老龄化艺术网络的活动将提供一个不断增长的跨学科研究人员网络，一个经过跨学科培训的蓬勃发展的早期职业研究人员社区，一个广泛和积极参与的利益相关者社区，一个发展网络和发展英国基础设施的明确路线图，以及显示我们整个生命过程中健康老龄化翻译平台的初步概念验证的项目。它将在研究人员之间产生新的合作，这些研究人员具有开发可信的应用程序以获得进一步资金所需的临界质量。通过提供额外的资金，从而有能力进行更多的研究，我们的健康老龄化艺术网络将加快英国和国际上的翻译性老龄化研究，以实现改善所有人的健康寿命的目标。

项目成果

Towards interpretable machine learning for clinical decision support

走向可解释的机器学习以支持临床决策

• 发表时间: 2022
• 作者: B. Walters

Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study.

高龄成人淋巴细胞区室的免疫衰老特征和多种长期病症（多发病）：Newcastle 85 研究。

• DOI: 10.1016/j.mad.2022.111739
• 发表时间: 2022
• 期刊: Mechanisms of ageing and development
• 影响因子: 5.3
• 作者: Granic A

Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial.

• DOI: 10.1371/journal.pone.0294330
• 发表时间: 2023
• 期刊: PloS one
• 影响因子: 3.7

Advanced glycation end products in skeletal muscle health and sarcopenia: A systematic review of observational studies.

骨骼肌健康和肌肉减少症中的高级糖基化终产物：观察性研究的系统回顾。

• DOI: 10.1016/j.mad.2022.111744
• 发表时间: 2023
• 期刊: Mechanisms of ageing and development
• 影响因子: 5.3
• 作者: Granic A

Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study.

• DOI: 10.1007/s11357-023-00869-4
• 发表时间: 2024-02
• 期刊: GEROSCIENCE
• 影响因子: 5.6
• 作者: Habiballa, Leena;Hruby, Adam;Granic, Antoneta;Dodds, Richard M.;Hillman, Susan J.;Jurk, Diana;Passos, Joao F.;Sayer, Avan A.
• 通讯作者: Sayer, Avan A.