The BLAST Network: Building Links in Ageing Science and Translation

BLAST 网络:建立老龄科学与翻译的联系

基本信息

  • 批准号:
    BB/W01825X/1
  • 负责人:
  • 金额:
    $ 56.96万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2022
  • 资助国家:
    英国
  • 起止时间:
    2022 至 无数据
  • 项目状态:
    未结题

项目摘要

Ageing of human populations poses fundamental economic and social challenges. By 2050, for the first time in human history, there will be as many old people on Earth over the age of 65 as children under 15. It is extremely rare to grow old in good health, and by the age of 85 essentially everyone suffers at least one significant chronic disease. As COVID-19 has so clearly shown, older people are also at high risk of harm from infectious diseases. In the UK, it has been estimated that ~40% of the total budget of the NHS (£120 billion) is spent combating the consequences of ageing in poor health. The UK government has pledged to increase healthy life expectancy of the UK population by an extra 5 years (HLE+5) by 2035. Hitting this target will greatly improve individual quality of life as well as adding enormously to national productivity and wealth. This goal is potentially possible because of significant advances in basic research that has discovered what makes people age, how the ageing process can lead to many different diseases associated with ageing, and - importantly - new drugs and other treatments that can improve health in old age. Some of these treatments are already looking exciting in human clinical trials.However, despite all these advances, there is a lack of joined-up thinking and information sharing between basic scientists, drug developers, doctors and those approving drugs for human use, which is holding back progress in improving the health of older people. We will overcome these hurdles by bringing together people who can make the progress happen, encouraging them to work collaboratively to solve big problems. We will also help train up new researchers, support new research to test novel ideas and provide easy-to-access information on ageing research advances for people working in health care and health policy. Importantly, we will engage with the general public including older people to gain their insights on what research should be done, as well as presenting to them what we plan to do and what we have achieved.
人口老龄化构成了根本性的经济和社会挑战。到2050年,地球上65岁以上的老年人将首次与15岁以下的儿童一样多。健康地变老是极其罕见的,到85岁时,几乎每个人都至少患有一种严重的慢性病。正如新冠肺炎已经清楚地表明的那样,老年人也面临着受到传染病伤害的高风险。在英国,据估计,NHS总预算(1200亿GB)的40%左右用于对抗健康状况不佳的老龄化后果。英国政府承诺到2035年将英国人口的健康预期寿命增加5年(HLE+5)。实现这一目标将极大地提高个人生活质量,并极大地增加国家生产率和财富。这一目标是可能实现的,因为基础研究取得了重大进展,发现了是什么让人衰老,衰老过程如何导致与衰老相关的许多不同疾病,以及--重要的是--可以改善老年健康的新药和其他治疗方法。其中一些治疗方法已经在人体临床试验中看起来很令人兴奋。然而,尽管取得了所有这些进展,但基础科学家、药物开发商、医生和那些批准人类使用药物的人之间缺乏统一的思维和信息共享,这阻碍了改善老年人健康的进展。我们将克服这些障碍,把能够取得进展的人聚集在一起,鼓励他们通力合作,解决重大问题。我们还将帮助培训新的研究人员,支持新的研究以测试新的想法,并为医疗保健和卫生政策工作人员提供关于老龄化研究进展的易于获取的信息。重要的是,我们将与包括老年人在内的公众接触,了解他们对应该做什么研究的见解,并向他们介绍我们计划做的事情和我们取得的成就。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Linking interdisciplinary and multiscale approaches to improve healthspan-a new UK model for collaborative research networks in ageing biology and clinical translation.
将跨学科和多尺度方法联系起来以改善健康寿命——英国衰老生物学和临床转化合作研究网络的新模式。
An auxin-inducible, GAL4-compatible, gene expression system for Drosophila.
  • DOI:
    10.7554/elife.67598
  • 发表时间:
    2022-04-01
  • 期刊:
  • 影响因子:
    7.7
  • 作者:
    McClure CD;Hassan A;Aughey GN;Butt K;Estacio-Gómez A;Duggal A;Ying Sia C;Barber AF;Southall TD
  • 通讯作者:
    Southall TD
Quantum Healthy Longevity for healthy people, planet, and growth.
量子健康长寿,促进健康的人类、地球和经济增长。
  • DOI:
    10.1016/s2666-7568(22)00267-7
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Woods T
  • 通讯作者:
    Woods T
Therapeutic Opportunities Presented by Modulation of Cellular Senescence.
细胞衰老调节带来的治疗机会。
  • DOI:
    10.1007/978-3-031-21410-3_8
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Faragher RGA
  • 通讯作者:
    Faragher RGA
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Richard Faragher其他文献

Richard Faragher的其他文献

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{{ truncateString('Richard Faragher', 18)}}的其他基金

Anglo Japanese Global Partnering Award
英日资源全球合作奖
  • 批准号:
    BB/Y006984/1
  • 财政年份:
    2023
  • 资助金额:
    $ 56.96万
  • 项目类别:
    Research Grant
Bioartificial interventions for organ senescence: Understanding and preventing senescence induced by liver toxins (SILT) in hepatocytes.
器官衰老的生物人工干预:了解和预防肝细胞中肝毒素(SILT)诱导的衰老。
  • 批准号:
    MR/Y010299/1
  • 财政年份:
    2023
  • 资助金额:
    $ 56.96万
  • 项目类别:
    Research Grant

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