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STRATEGY FOR THE CHARACTERIZATION OF THE HUMAN GENOME

STRATEGY FOR THE CHARACTERIZATION OF THE HUMAN GENOME
人类基因组表征策略
批准号：
3287197
负责人：
LEONARD S LERMAN
金额：
$26.48万
依托单位：
GENETICS INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
项目状态：
已结题
起止时间：
1985-09-01 至 1987-08-31
来源：
https://reporter.nih.gov/project-details/3287197
关键词：
DNA biological polymorphism complementary DNA gel electrophoresis genetic manipulation genetic mapping genome human tissue image processing nucleic acid sequence nucleic acid structure nucleobase temperature

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中文摘要
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英文摘要
The program is concerned with the detection and analysis of sequence variations in the human genome, particularly those responsible for genetic disease or useful in following those variants. We will depend largely on the system of sequence-defined DNA separations of Fischer and Lerman and extend the system, both in its experimental capability and in theoretical basis of its function. We will also pursue certain structural and thermodynamic questions, particularly those bearing on the relations between sequence and the stability of the helix with respect to melting.
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STRATEGY FOR THE CHARACTERIZATION OF THE HUMAN GENOME
CHARACTERIZATION OF THE HUMAN GENOME
CHARACTERIZATION OF THE HUMAN GENOME
STRATEGY FOR THE CHARACTERIZATION OF THE HUMAN GENOME
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