课题基金 / 基金详情

STRUCTURE AND ACTIVITY OF RIBOSOMAL GENES IN PHYSARUM

STRUCTURE AND ACTIVITY OF RIBOSOMAL GENES IN PHYSARUM
粘菌核糖体基因的结构和活性
批准号:
3288658
负责人:
EDWARD M. JOHNSON
金额:
$9.81万
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-04-01 至 1987-03-31

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中文摘要
翻译
这个项目涉及编码核糖体RNA的基因在低等真核生物
英文摘要
This project concerns the genes coding for ribosomal RNA in the lower eukaryote Physarum polycephalum. These genes are located on a giant palindromic DNA molecule which is predominantly extrachromosomal in plasmodia. They can be isolated in milligram quantities together with their associated histones and regulatory proteins. We have cloned restriction fragments of the ribosomal genes and intend to sequence important transcriptional regulatory regions and intervening sequences. We shall elucidate the origin and functions of specific single-strand gaps and tightly-bound proteins at the rDNA termini. We shall examine the association of the rDNA palindrome with chromosomal DNA components. Through use of fluorescent-labeled histone we shall determine the nature of nucleosome structural changes which occur during transcription. We shall continue to examine the location and structure of nucleosomes on transcriptional regulatory sequences and on transcribed and non-transcribed rDNA regions.
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PROTEINS MEDIATING INTERACTION OF HIV 1 AND JCV IN CNS
Proteins Mediating Interaction of HIV-1 and JCV in CNS
Proteins Mediating Interaction of HIV-1 and JCV in CNS
  • 批准号:
    7382577
  • 项目类别:
  • 资助金额:
    $42.35万
  • 财政年份:
    1996
  • 负责人:
    EDWARD M. JOHNSON
  • 依托单位:
PROTEINS MEDIATING INTERACTION OF HIV 1 AND JCV IN CNS
海外基金