MEDCHANISM, ACTIVATION, & CONTROL OF RRNA TRANSCRIPTION
机制、激活、
基本信息
- 批准号:3291940
- 负责人:
- 金额:$ 18.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-07-01 至 1995-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In E. coli, the synthesis of ribosomes is controlled primarily at the stage
of rRNA transcription initiation. rRNA can account for as much as 50% of
instantaneous cellular RNa synthesis. In order to understand the
biosynthesis of the protein synthetic apparatus, factors involved in the
upstream activation and growth rate dependent regulation of rRNA synthesis
are being investigated. The mechanism of rRNA promoter-RNa polymerase
asociation is being studied using kinetic and footprinting methods. This
will lead to the identification of the individual steps involved in
transcription initiation at the rrnB P1 promoter and the factors that
influence each step. The specific DNA sequences required for upstream
activation and growth rate control will be defined by construction and
selection of site mutations, followed by assay of operon fusions in vivo.
Finally, the importance of position, orientation, and conformation of the
upstream activator sequence (UAS) relative to the promoter and the
feasibility of using the UAS to enhance transcription from heterologous
promoters will also be examined using operon fusions in vivo.
在大肠杆菌中,核糖体的合成主要在这一阶段受到控制
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Richard L. Gourse其他文献
Advances in bacterial promoter recognition and its control by factors that do not bind DNA
细菌启动子识别的进展及其受不结合 DNA 的因子的控制
- DOI:
10.1038/nrmicro1912 - 发表时间:
2008-06-03 - 期刊:
- 影响因子:103.300
- 作者:
Shanil P. Haugen;Wilma Ross;Richard L. Gourse - 通讯作者:
Richard L. Gourse
Richard L. Gourse的其他文献
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{{ truncateString('Richard L. Gourse', 18)}}的其他基金
INVESTIGATION OF THE BINDING SITE OF RNA POLYMERASE ON DKSA
DKSA 上 RNA 聚合酶结合位点的研究
- 批准号:
7954670 - 财政年份:2009
- 资助金额:
$ 18.22万 - 项目类别:
Mechanism, Activation, and Control of rRNA Transcription
rRNA 转录的机制、激活和控制
- 批准号:
7906337 - 财政年份:2009
- 资助金额:
$ 18.22万 - 项目类别:
FASEB CONFERENCE/PROKARYOTIC TRANSCRIPTION INITIATION
FASEB 会议/原核转录启动
- 批准号:
2192135 - 财政年份:1995
- 资助金额:
$ 18.22万 - 项目类别:
FASEB CONFERENCE--PROKARYOTIC TRANSCRIPTION INITIATION
FASEB 会议--原核转录启动
- 批准号:
3435215 - 财政年份:1993
- 资助金额:
$ 18.22万 - 项目类别:
MECHANISM, ACTIVATION AND CONTROL OF RRNA TRANSCRIPTION
RRNA转录的机制、激活和控制
- 批准号:
2178655 - 财政年份:1988
- 资助金额:
$ 18.22万 - 项目类别:
Mechanism, Activation, and Control of rRNA Transcription
rRNA 转录的机制、激活和控制
- 批准号:
7076951 - 财政年份:1988
- 资助金额:
$ 18.22万 - 项目类别:
Mechanism, Activation, and Control of rRNA Transcription
rRNA 转录的机制、激活和控制
- 批准号:
6684219 - 财政年份:1988
- 资助金额:
$ 18.22万 - 项目类别:
Mechanism, Activation, and Control of rRNA Transcription
rRNA 转录的机制、激活和控制
- 批准号:
7880622 - 财政年份:1988
- 资助金额:
$ 18.22万 - 项目类别:
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