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STRUCTURE OF DNA--SPECTROSCOPIC STUDIES

STRUCTURE OF DNA--SPECTROSCOPIC STUDIES
DNA 的结构——光谱研究
批准号：
3288652
负责人：
JOHN C SUTHERLAND
金额：
$9.51万
依托单位：
ASSOCIATED UNIV-BROOKHAVEN NATL LAB
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
项目状态：
已结题
起止时间：
1986-01-01 至 1990-12-31
来源：
https://reporter.nih.gov/project-details/3288652
关键词：
DNA acetylaminofluorene benzopyrenes circular dichroism conformation electronic spectra fluorescence polarization fluorescence spectrometry hydrogen bond mithramycin nucleic acid sequence nucleic acid structure polynucleotides

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中文摘要
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英文摘要
The three dimensional structure of DNA as influenced by base sequence, metal ions, chemical carcinogens and other agents will be studied by vacuum-ultraviolet circular dichroism (VUV-CD) and time resolved fluorescence. The electronic states and transitions of the DNA bases, understanding of which is crucial to the interpretation of CD spectra, will be studied using vacuum-ultraviolet magnetic circular dichroism (VUV-MCD) and fluorescence polarization spectroscopy. A major goal is understanding why VUV-CD is a better indicator of the helical structure of, and more sensitive to the hydrogen bonding between DNA strands than is conventional, longer wavelength CD. The VUV-CD, VUV-MCD, fluorescence polarization and time-resolved fluorescence experiments will be performed at the National Synchrotron Light Source.
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