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ENDOCRINE FUNCTION AND STRUCTURE OF RELAXIN

ENDOCRINE FUNCTION AND STRUCTURE OF RELAXIN
松弛素的内分泌功能和结构
批准号：
3311313
负责人：
christian none schwabe
金额：
$13.37万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
项目状态：
已结题
起止时间：
1977-02-01 至 1987-02-28
来源：
https://reporter.nih.gov/project-details/3311313
关键词：
RNA methylation aminoacid analyzer centrifugation chemical structure function electron microscopy embryo /fetus pharmacology fluorimetry gel electrophoresis gel filtration chromatography high performance liquid chromatography histochemistry /cytochemistry hormone biosynthesis hormone regulation /control mechanism human tissue immunoelectroadsorption immunofluorescence technique membrane activity radioimmunoassay radiotracer relaxin reproductive hormone saltwater environment scintillation spectrometry secretion tissue /cell culture

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英文摘要
The ultimate objective of this study is to elucidate the endocrine function of relaxin and to determine which of the structural features of the hormone is essential for the response in the target cells. The investigation will include the study of the mechanism of biosynthesis of relaxin, its secretion and transfer to the target cells. Experiments have been designed to elucidate the mode of relaxin-receptor interaction and the nature of the primary cellular response to relaxin stimulation. Another aspect of this work will be concerned with the mechanism of the macromolecular remodelling of the symphysis pubis, the major target organ of relaxin. Finally an attempt will be made to determine whether relaxin mediates its response via a different factor or whether relaxin itself is a factor dependent upon growth hormone for its action. Structural studies of the shark relaxin from Odontaspis tauris will be continued.
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