ENDOCRINE FUNCTION AND STRUCTURE OF RELAXIN

本研究的最终目的是阐明 松弛素，并确定该激素的结构特征， 对靶细胞的反应至关重要。 评估包括 松弛素的生物合成、分泌和代谢机制的研究 转移到目标细胞。 设计了实验来阐明 松弛素-受体相互作用的模式和主要细胞的性质 对松弛素刺激的反应。 这项工作的另一个方面将受到关注 在耻骨联合大分子重塑的机制下， 松弛素的主要靶器官。 最后，将尝试确定 松弛素是否通过不同的因子介导其反应，或者松弛素是否 生长激素本身是一种依赖于生长激素发挥作用的因子。 本文将对来自Odontaspis tauris的鲨鱼松弛素进行结构研究。 持续期间内的

The ultimate objective of this study is to elucidate the endocrine function of relaxin and to determine which of the structural features of the hormone is essential for the response in the target cells. The investigation will include the study of the mechanism of biosynthesis of relaxin, its secretion and transfer to the target cells. Experiments have been designed to elucidate the mode of relaxin-receptor interaction and the nature of the primary cellular response to relaxin stimulation. Another aspect of this work will be concerned with the mechanism of the macromolecular remodelling of the symphysis pubis, the major target organ of relaxin. Finally an attempt will be made to determine whether relaxin mediates its response via a different factor or whether relaxin itself is a factor dependent upon growth hormone for its action. Structural studies of the shark relaxin from Odontaspis tauris will be continued.