SEX CHROMOSOMAL ABNORMALITIES: A PROSPECTIVE STUDY

这项研究的目的是继续我们对一群儿童的研究 在细胞遗传学中发现的性染色体异常 对1964-1974年间40,000名连续出生的婴儿进行的调查。 我们的长期目标是确定每一种疾病的最终预后 条件--47，XXX；47，XXY；47，XYY；45，X及其嵌合体。数据来自 具有这些核型的儿童和成人的有偏见的样本表明，他们 智力、情感、社交或身体方面的风险增加 晚年生活中的问题。这项“家庭发展研究”的数据是 通过亚组间比较和染色体正常进行分析 兄弟姐妹作为对照。我们认为语言发展的延迟是一种 提出了许多重要问题的建议，并正在进行深入研究 在这片区域。 首席调查员和他的同事们一直在接受所有人的询问 关于宫内确诊的胎儿的预后 这些核型，从而强调了这些持续的 学习。

The purpose of this research is to continue our study of a group of children with abnormalities of the sex chromosomes who were identified in a cytogenetic survey of 40,000 consecutive births from 1964-1974. Our long-term objective is to define the ultimate prognosis for each of these conditions--47,XXX; 47,XXY; 47,XYY; 45,X and mosaicisms of these. Data from biased samples of children and adults with these karyotypes indicate that they are at an increased risk for intellectual, emotional, social or physical problems in later life. The data from this "Family Development Study" are being analyzed by comparisons between subgroups and by using chromosomally normal siblings as controls. We have identified delayed language development as an important problem in many of the propositi, and are conducting an in-depth study in this area. The chief investigator and his associates have been receiving inquiries from all over the world as to the prognosis of fetuses identified in utero as having these karyotypes, thus stressing one significant result of these continuing studies.