SEX CHROMOSOMAL ABNORMALITIES: A PROSPECTIVE STUDY

性染色体异常：一项前瞻性研究

• 批准号: 3311220
• 负责人: ARTHUR ROBINSON
• 金额: $ 13万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3311220
• 关键词: adolescence (12-20); aneuploidy; behavior test; behavioral genetics; child physical development; child psychology; chromosome disorders; cytogenetics; developmental genetics; developmental neurobiology; environmental stressor; genetic disorder diagnosis; human population genetics; human subject; job performance; job satisfaction; karyotype; learning; longitudinal human study; middle childhood (6-11); neuroendocrine system; neuromuscular system; neuropsychology; psychosomatic disorders; respiratory circulation; sex behavior; sex chromosomes; social adjustment; stress; young adult human (21-34)

The long-term objectives of this study are to continue to establish the developmental course of a group of individuals with sex chromosome aneuploidy identified at birth in an unbiased fashion. Sixty-eight propositi were identified by checking the sex chromatin status of 40,371 consecutive births in two Denver hospitals from 1964 to 1974. Forty-six of these have been followed with their families prospectively since birth in this Family Development Study. Wherever possible, siblings are used as controls. The original propositi will be either in late adolescence or early adult-hood. Gender identity, sexual and reproductive activity, and adaptation to adult life will be documented. Neuromuscular, neuropsychological, psychiatric, and endocrine evaluation will be particularly emphasized. The nature of the interaction between propositi, their families, and their peers will be documented.

本研究的长期目标是继续建立 一群具有性染色体的个体的发育过程 以公正的方式在出生时鉴定出非整倍体。 六十八 通过检查 40,371 人的性染色质状态来确定命题 1964 年至 1974 年间，丹佛两家医院连续分娩。其中 46 例 这些人自出生以来一直受到家人的跟踪 这项家庭发展研究。 只要有可能，兄弟姐妹都会被用作 控制。 最初的命题要么是在青春期后期，要么是 成年早期。 性别认同、性和生殖活动，以及 对成人生活的适应将被记录下来。 神经肌肉， 神经心理学、精神病学和内分泌评估将 特别强调。 命题之间相互作用的本质， 他们的家人和同龄人将被记录在案。