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DETOXIFICATION OF ORGANOPHOSPHONIC ACIDS

DETOXIFICATION OF ORGANOPHOSPHONIC ACIDS
有机膦酸的解毒
批准号:
3290781
负责人:
JOHN W FROST
金额:
$7.82万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-04-01 至 1989-03-31

项目摘要

项目成果

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相关文献

中文摘要
翻译
多年来,大肠杆菌已经发展出了独特的衍生方式
英文摘要
Over the ages, E. coli have developed ingenious means for deriving nutrients from scavanging and degradation. A currently ill-defined element of this degradative capacity can detoxify organophosphonic acids by cleaving the carbon to phosphorus bond which characterizes these molecules. The proposed research is designed to: 1. Define the organic chemistry exploited by E. coli in their degradation of phosphonic acids. 2. Isolate the enzyme(s) which catalyze the observed degradation. 3. Identify the genes involved in degradation of phosphonic acids by E. coli. By forging together organic chemistry, enzymology and molecular biology, this study seeks a mechanism-based understanding of naturally occurring detoxification.
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Shikimate Pathway Variants
  • 批准号:
    6465605
  • 项目类别:
  • 资助金额:
    $28.23万
  • 财政年份:
    2002
  • 负责人:
    JOHN W FROST
  • 依托单位:
Shikimate Pathway Variants
  • 批准号:
    6623429
  • 项目类别:
  • 资助金额:
    $25.1万
  • 财政年份:
    2002
  • 负责人:
    JOHN W FROST
  • 依托单位:
Shikimate Pathway Variants
  • 批准号:
    6727606
  • 项目类别:
  • 资助金额:
    $25.12万
  • 财政年份:
    2002
  • 负责人:
    JOHN W FROST
  • 依托单位:
Shikimate Pathway Variants
  • 批准号:
    6875012
  • 项目类别:
  • 资助金额:
    $25.12万
  • 财政年份:
    2002
  • 负责人:
    JOHN W FROST
  • 依托单位:
海外基金