INHIBITION OF NAD DEPENDENT SYNTHASES

肌醇1-磷酸(MIP)合成酶是一种NAD依赖性酶 将D-葡萄糖-6-磷酸转化为肌醇-1-磷酸。我们的 研究试图回答与此有关的机械性问题 酶转化。为了回答这些问题，底物类似物 酶结合底物、活性中间体和过渡 状态是综合的。这些类似物在体外用MIP进行测试 合酶，以获得对机制途径的洞察。抑制 MIP合酶可能产生新的和有效的抑制物，可能导致 为躁郁症的新疗法干杯。质谱学(EI-FAB 和MALDI-MS)是用于 我们的化合物的特性。

myo-Inositol 1-phosphate (MIP) synthase is an NAD dependent enzyme that converts D-Glucose 6-phosphate to myo-Inositol 1-phosphate. Our research seeks to answer the mechanistic questions regarding this enzymatic conversion. To answer these questions, substrate analogues of enzyme-bound substrates, reactive intermediates and transition states are synthesized. These analogues are tested in vitro with MIP synthase to gain insight towards the mechanistic pathway. Inhibition of MIP synthase may produce novel and potent inhibitors that may lead to new treatments for manic depression. Mass spectroscopy (EI- FAB and MALDI-MS) is a standard analytical technique used in the characterization of our compounds.