BEHAVIOR, HORMONES AND BIOLOGICAL CLOCKS

行为、激素和生物钟

• 批准号: 3310183
• 负责人: IRVING ZUCKER
• 金额: $ 15.75万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-08-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3310183
• 关键词: animal ecology; appetite regulatory center; bioenergetics; biological clocks; body weight; circadian rhythms; eating; experimental brain lesion; female; hormone regulation /control mechanism; hypothalamus; male; male castration; neuroendocrine system; nutrition related tag; obesity; ovariectomy; overeating; pineal body; psychobiology; seasons; sex cycle; suprachiasmatic nucleus; testosterone

The main aims of the proposed work are to identify and characterize the external and internal factors that mediate seasonal cycles in reproduction and energy balance and to elaborate the neural substrates that generate circadian rhythms in behavior and physiology of mammals. The model species to be studied are the meadow vole and the Syrian hamster. Specific projects include 1) determining the role of testicular hormones in mediating the decline in body weight and food intake that occurs during fall and winter, 2) the contribution of gonadal hormones to individual differences in food intake and body weight, 3) the role of photoperiod in inducing refractoriness to the weight-promoting effects of androgens, 4) the influence of the pineal gland in mediating the effects of photoperiod on energy balance, 5) specification of the neural pathways by which photoperiod influences food intake and body mass, 6) the role of photoperiod in counteracting the obesities produce by ovariectomy or by destruction of the ventromedial nuclei of the hypothalamus, 7) specification of the degree of redundancy in the mediation of circadian rhythms by the suprachiasmatic nuclei. Parameters to be measured include body weight, food intake, locomotor activity, testosterone levels in plasma and several other indices of reproductive status or energy balance. The proposed research will develop concepts and data relevant to understanding and manipulation of human circadian rhythms as well as for the control of food intake and body mass through non-invasive means.

拟议工作的主要目的是确定和描述