PSYCHOPHYSICS OF THE STARTLE REACTION

惊吓反应的心理物理学

• 批准号: 3311308
• 负责人: HOWARD HOFFMAN
• 金额: $ 15.44万
• 依托单位: BRYN MAWR COLLEGE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-01-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3311308
• 关键词: aminoglycoside antibiotics; disease /disorder proneness /risk; human subject; hypoxia neonatorum; neural facilitation; neural inhibition; newborn human (0-6 weeks); ototoxin; premature infant human; psychobiology; psychophysics; sensory disorders; startle reaction; sudden infant death syndrome; young adult human (21-34)

Previous research in this and in other laboratories indicates that certain elicited reflexes can be modified (either augmented or inhibited) if the reflex eliciting event is accompanied by a mild exteroceptive stimulus at an appropriate lead interval. For example, either a weak tone or a dim flash of light can inhibit the startle reaction to a loud sound in th rat and it can inhibit the reflexive eyeblink that is elicited by a tap to the forehead in humans. The present sequence of investigations is designed to document the earliest manifestations of reflex modification in human infants and to compare them to those of adults. In addition to examining reflex modification effects in healthy day old full-term infants, the work will study these effects in infants who are at risk for deficits in sensorineural processing. Subject populations will include infants who are premature or of low birth weight, or suffering from perinatal aphyxia, as well as infants exposed to aminoglycoside therapy and those at risk for SIDS.

之前在这个实验室和其他实验室的研究表明，某些 在以下情况下，可以修改(增强或抑制)诱发的反射 反射诱发事件伴随着轻微的外部感觉刺激。 适当的提前期间隔。例如，要么是弱音，要么是暗淡 闪光可抑制大鼠对大鼠的惊恐反应 它还可以抑制由轻敲鼠标引起的反射性眨眼 人类的额头。目前的调查顺序旨在 记录人类反射改变的最早表现 并将其与成人进行比较。除了检查 健康日龄足月儿的反射矫正效果研究 将研究这些对婴儿的影响，这些婴儿有缺陷的风险 感觉神经加工。受试人群将包括以下婴儿 早产的早产的、出生体重低的或患有围产期过敏的，如 以及接受氨基糖苷类药物治疗的婴儿和那些有患上 小岛屿发展中国家。