PLANE FACTS ON THE MODE OF ACTION OF BICYCLOMYCIN

双环霉素（1）是一种临床上有用的抗生素。 收集的信息 从正在进行的研究提供了基础，我们目前的概念， 关于1的作用方式。 不幸的是， 关于药物活化过程，关键步骤的能量学，以及 抗生素与受体位点的相互作用。 在这 建议，双环霉素的作用模式的一种新的假设， 被先进。 已经概述了一种综合办法， 了解药物和受体位点的功能。 详细 还提出了实验来辨别所提供的效果， 生物介质中的药物活化和结合过程。 知识 这种一般性质的预期提供了分子基础， 这一领域的后续研究，并允许未来的一般药物设计， 在较少的经验基础上进行。

Bicyclomycin (1) is a clinically useful antibiotic. Information gleaned from ongoing studies have provided the basis of our current notions concerning the mode of action of 1. Unfortunately, little is known concerning the drug activation process, the energetics of key steps, and the interaction of the antibiotic with the receptor site(s). In this proposal, a novel hypothesis for the mode of action of bicyclomycin has been advanced. An integrated approach has been outlined for the further understanding of how the drug and the receptor site function. Detailed experiments are also proposed to discern the effects provided by the biological medium in the drug activation and binding process. Knowledge of this general nature is expected to provide the molecular basis for subsequent research in this area, and allow future general drug design to proceed on a less empirical basis.