FLU:Trailmap: Transmission and risk of avian influenza: learning more to advance preparedness

FLU:路线图:禽流感的传播和风险:了解更多信息以做好准备

基本信息

  • 批准号:
    BB/Y007271/1
  • 负责人:
  • 金额:
    $ 102.83万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    未结题

项目摘要

High pathogenicity avian influenza virus (HPAIV) is a significant burden on animal health globally and threatens human health. Incursions of HPAIV into the UK have increased significantly since 2020 with over 350 infected premises being detected between 2020 and 2023. Wild bird populations have also suffered significant mortalities across multiple species, with a shift to infection of seabirds enabling over-summering of virus infection in UK birds for the first time. Whilst virus incursions have been restricted to the H5N1 subtype, the ability of these viruses to exchange genetic material means that over 12 different H5N1 viruses have been detected in the UK. Further, the increased infection pressure has meant that the virus has spilt over into scavenging mammalian species with 23 detections of HPAIV in wild mammals since 2020. This project is in response to this extreme increase in detection of HPAIV infection in the UK and is divided across five work packages (WPs) to improve our understanding of HPAIVs, help mitigate incursions and refine approaches to future prevention strategies. Work-package (WP1) will improve our understanding of on-farm biosecurity practices, to define weaknesses in existing barriers and determine how to implement effective counter measures. Through detailed investigation and by conducting multi-sectorial interviews, the adherence and effectiveness of existing biosecurity interventions will be assessed. Outputs will provide insight into effectiveness and challenges to implementation which will be used to improve biosecurity in the field.WP2 will improve our understanding of factors which contribute to the circulation of these viruses, including understanding the complex interactions amongst wild bird networks and with poultry. Viral genetic and epidemiological data from the field, and data generated through the other WPs, will be input into models that will provide insight into 'high-risk' activities. Modelling populations and their interactions will link WP1 and WP5 to help understand the effectiveness and impact of existing and future control and mitigation actions.WP3 will improve our understanding of HPAIV transmission dynamics in both wild birds and poultry. By undertaking biological sampling across wild bird populations, we will develop risk-based surveillance programmes and model interactions at wild bird and poultry interfaces. This will enable a definition of high-risk incursion sites and critical wild bird populations responsible for potential sustained transmission within the environment. Outputs will feed into WP2 and enable a greater understanding of the potential reservoirs of infection as well as factors that drive incursion of disease from bird reservoirs into the poultry sector.WP4 will assess virological factors that drive differential disease outcomes. Both viral infectivity and factors that dictate infection of different species will be assessed. This will enhance our understanding of virological interactions and define the role of viral factors that contribute to viral emergence. This WP will also link to outputs from other WPs to examine the mechanisms that drive viral diversity and factors that may enable adaptation to different hosts.Finally, WP5 will assess the role of host factors, including immunity, in governing susceptibility, outcome, epidemiology, and virus evolution. This WP will investigate how molecular differences between species contribute to disease outcomes and define how antibody responses to different virus proteins impact upon the potential of virus emergence including variations across different hosts. Viral domains that are identified as being important in the emergence of escape mutants will be further investigated to define where flex exists within viral proteins targeted by the host immune response. We will also assess how the implementation of vaccination might impact on outbreaks and hence will inform future mitigation strategies.
高致病性禽流感病毒(HPAIV)是全球动物健康的重大负担,并威胁人类健康。自2020年以来,HPAIV入侵英国的情况显着增加,2020年至2023年期间检测到超过350个受感染的场所。野生鸟类种群在多个物种中也遭受了重大死亡,海鸟感染的转变使英国鸟类首次出现病毒感染的夏季。虽然病毒入侵仅限于H5N1亚型,但这些病毒交换遗传物质的能力意味着在英国已检测到超过12种不同的H5N1病毒。此外,感染压力的增加意味着该病毒已扩散到食腐性哺乳动物物种中,自2020年以来在野生哺乳动物中检测到23例HPAIV。该项目是为了应对英国HPAIV感染检测的极端增加,分为五个工作包(WP),以提高我们对HPAIV的理解,帮助减轻入侵并改进未来预防策略的方法。工作包(WP1)将提高我们对农场生物安全实践的理解,确定现有障碍的弱点,并确定如何实施有效的应对措施。通过详细调查和多部门访谈,将评估现有生物安保干预措施的遵守情况和有效性。产出将提供对实施的有效性和挑战的深入了解,这些将用于改善实地的生物安全。WP 2将提高我们对这些病毒传播因素的理解,包括理解野鸟网络之间以及与家禽之间的复杂相互作用。来自该领域的病毒遗传和流行病学数据以及通过其他WP生成的数据将输入模型,以深入了解“高风险”活动。对种群及其相互作用的建模将把WP1和WP5联系起来,以帮助了解现有和未来控制和缓解行动的有效性和影响。WP3将提高我们对HPAIV在野生鸟类和家禽中传播动态的理解。通过对野生鸟类种群进行生物采样,我们将制定基于风险的监测方案,并建立野生鸟类和家禽相互作用的模型。这将有助于确定高风险入侵地点和造成环境中潜在持续传播的关键野生鸟类种群。结果将输入WP2,使人们能够更好地了解潜在的感染宿主以及驱动疾病从鸟类宿主侵入家禽部门的因素。WP4将评估驱动不同疾病结果的病毒学因素。将评估病毒感染性和决定不同种属感染的因素。这将增强我们对病毒学相互作用的理解,并确定有助于病毒出现的病毒因子的作用。本工作计划还将与其他工作计划的结果相联系,以研究驱动病毒多样性的机制和可能使其适应不同宿主的因素。最后,工作计划5将评估宿主因素(包括免疫力)在控制易感性、结局、流行病学和病毒进化方面的作用。本WP将研究物种之间的分子差异如何影响疾病结果,并确定抗体对不同病毒蛋白的反应如何影响病毒出现的可能性,包括不同宿主之间的变异。将进一步研究被鉴定为在逃逸突变体的出现中重要的病毒结构域,以确定宿主免疫应答靶向的病毒蛋白中存在的flex。我们还将评估接种疫苗的实施如何影响疫情,从而为未来的缓解策略提供信息。

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Ian Brown其他文献

Genome sequences of hemagglutinin cleavage site predict the pathogenicity phenotype of avian influenza virus: statistically validated data for facilitating rapid declarations and reducing reliance on in vivo testing.
血凝素裂解位点的基因组序列预测禽流感病毒的致病性表型:经过统计验证的数据,可促进快速声明并减少对体内测试的依赖。
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Dong;M. Torchetti;M. Killian;Ian Brown;D. Swayne
  • 通讯作者:
    D. Swayne
Teaching computer literacy.
教授计算机知识。
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Chris Corbel;Paul Gruba;Louise Melov;Kris Clarke;Helen Lavery;Ligare Pty Ltd;Adele Collins;Ali Baharlou;Andy Pike;Fiona Thurn;Guy Noble;Ian Brown;Marina Sherbak;Najia Haimd;Rodolfo Cares;Tim Lever;Maree Derwent
  • 通讯作者:
    Maree Derwent
Polyps and polypoid lesions of the anus
  • DOI:
    10.1016/j.mpdhp.2013.12.001
  • 发表时间:
    2014-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Mark Bettington;Ian Brown
  • 通讯作者:
    Ian Brown
Autoimmune enteropathies
  • DOI:
    10.1007/s00428-017-2243-7
  • 发表时间:
    2017-10-11
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Sarah E. Umetsu;Ian Brown;Cord Langner;Gregory Y. Lauwers
  • 通讯作者:
    Gregory Y. Lauwers
Security against compelled disclosure
防止强制披露的保障

Ian Brown的其他文献

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{{ truncateString('Ian Brown', 18)}}的其他基金

Understanding animal health threats from emerging H5 high pathogenicity avian influenza viruses
了解新出现的 H5 高致病性禽流感病毒对动物健康的威胁
  • 批准号:
    BB/X006174/1
  • 财政年份:
    2022
  • 资助金额:
    $ 102.83万
  • 项目类别:
    Research Grant
Doctoral Dissertation: Caddo Salt Production in Northwestern Louisiana
博士论文:路易斯安那州西北部的卡多盐生产
  • 批准号:
    1416780
  • 财政年份:
    2014
  • 资助金额:
    $ 102.83万
  • 项目类别:
    Standard Grant
FRESNEL: FedeRatEd Secure sensor NEtwork Laboratory
FRESNEL:FedeRatEd 安全传感器网络实验室
  • 批准号:
    EP/G070687/1
  • 财政年份:
    2010
  • 资助金额:
    $ 102.83万
  • 项目类别:
    Research Grant
Enhanced detection and characterisation of emergent influenza A viruses and avian paramyxoviruses (APMV/NDV): An Anglo-Chinese exchange
加强新​​发甲型流感病毒和禽副粘病毒 (APMV/NDV) 的检测和表征:英中交流
  • 批准号:
    BB/G530384/1
  • 财政年份:
    2009
  • 资助金额:
    $ 102.83万
  • 项目类别:
    Research Grant
Combating Swine Influenza Initiative (model project)
抗击猪流感倡议(示范项目)
  • 批准号:
    BB/H014292/1
  • 财政年份:
    2009
  • 资助金额:
    $ 102.83万
  • 项目类别:
    Research Grant
Privacy Value Networks
隐私价值网络
  • 批准号:
    EP/G002606/1
  • 财政年份:
    2008
  • 资助金额:
    $ 102.83万
  • 项目类别:
    Research Grant
Virus transmission dynamics and the immune response of birds to avian influenza
病毒传播动力学和鸟类对禽流感的免疫反应
  • 批准号:
    BB/E010849/1
  • 财政年份:
    2007
  • 资助金额:
    $ 102.83万
  • 项目类别:
    Research Grant
Doctoral Dissertation Improvement Grant: Salt and Society: Late Woodland and Mississippian Interaction in Southwest Alabama
博士论文改进补助金:盐与社会:阿拉巴马州西南部的晚期林地和密西西比河的相互作用
  • 批准号:
    0437344
  • 财政年份:
    2004
  • 资助金额:
    $ 102.83万
  • 项目类别:
    Standard Grant

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  • 批准号:
    MR/Y03368X/1
  • 财政年份:
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  • 资助金额:
    $ 102.83万
  • 项目类别:
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  • 批准号:
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    2023
  • 资助金额:
    $ 102.83万
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