How cell shape regulators control cell competition in tissue development

该项目旨在确定细胞形状(极性)调节剂如何影响上皮组织中的细胞存活。当突变或损伤扰乱组织细胞中的细胞形状调节器时，信号通路就会改变，从而杀死异常细胞。一种被称为“细胞竞争”的监测机制对于清除受损细胞很重要。本项目将利用醋蝇、果蝇和哺乳动物系统，研究一种潜在的细胞竞争调节因子，酪氨酸磷酸酶PTP61F，以响应细胞形状调节因子的扰动。这项研究有望揭示可用于改善生物体适合性、提高生产力或降低虫害防治的生物标志物。

This project aims to determine how cell shape (polarity) regulators affect cell survival in an epithelial tissue. When mutation or wounding perturb cell shape regulators in a tissue cell, signalling pathways are altered that kill the aberrant cells. A surveillance mechanism termed "cell competition" is important to remove the damaged cells. This project will investigate a potential regulator of cell competition, the tyrosine phosphatase PTP61F, in response to perturbation of cell shape regulators, using the vinegar fly, Drosophila, and mammalian systems. This study is expected to reveal biomarkers that can be used to improve organismal fitness to increase productivity or to decrease it for pest control.