课题基金 / 基金详情

ENZYME IN ORGANIC SYNTHESIS--CONSTRUCTION OF POLYHYDROXY

ENZYME IN ORGANIC SYNTHESIS--CONSTRUCTION OF POLYHYDROXY
有机合成酶--多羟基的构建
批准号：
3303327
负责人：
CHI-HUEY WONG
金额：
$18.47万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
项目状态：
已结题
起止时间：
1989-09-01 至 1992-08-31
来源：
https://reporter.nih.gov/project-details/3303327
关键词：
O glycosidase aldehyde lyase carbohydrate analog carbohydrate biosynthesis chemical binding chemical condensation chemical structure function chemical synthesis cis trans isomerization covalent bond enzyme biosynthesis enzyme inhibitors gel electrophoresis nuclear magnetic resonance spectroscopy nucleic acid chemical synthesis pentose phosphate phosphomutase piperidine polyhydroxy compound pyrrolidines spermine

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中文摘要
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英文摘要
Many carbohydrates and derivatives are clinically important compounds or synthetically useful intermediates. The proposed investigation will develop practical procedures for the syntheses of carbohydrates and derivatives based on enzyme-catalyzed C-C bond and C-N bond formations. Six different aldolases will be used as catalysts for the syntheses of sugar related molecules of potential use as inhibitors of target enzymes. Nucleoside phosphorylase coupled with phosphopentomutase will be used for the synthesis of nucleosides useful as antiviral agents.
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