Position Specific Isotope Analysis (PSIA) / Is this approach a highly discriminating Environmental Forensics Tool?

位置特定同位素分析 (PSIA)/这种方法是一种具有高度辨别力的环境取证工具吗？

• 批准号: EP/D013739/2
• 负责人: Bob Kalin
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD013739%2F2
• 关键词: Position; Specific; Isotope; Analysis; PSIA

Here we propose a 'leap foward' with the application of Position Specific Isotope Analysis to Environmental Forensics, a topic which has a large un-tapped potential for biogeochemical / biodegradation studies. Compound specific isotope analysis (CSIA) is a relatively new methods in Enviornmental Forenscis (figuring out where the contamination in the environment comes from). PSIA could uncover / unlock the questions that CSIA has opened up and leap-frog our understanding of the fate of contaminants in the environment. Isotopic fractionation is limited to reactions at the site or bond in the contaminant molecule associated with the rate-limiting biodegradation step. These fractionation effects are diluted in 'whole molecule' CSIA by the presence of non-reacting carbon atoms. Intramolecular isotope ratios however would be sensitive to such fractionation effects and could be used to determine the pathways and mechanism of degradation. Leveraging the resources of Prof. Kalin's EPSRC funded Platform Grant therefore provides the 'base-line real-world' access to sites and samples for this proposed 'Speculative Engineering' research, thereby allowing the research proposed here to solely focus on solving the question: Is PSIA useful for Environmental Forensics applications?Current convention would say that PSIA is impracticable for the 'real world', however we challenge this and firmly believe in the potential of this approach. There are many other areas of research that may benefit from a concerted speculative research effort on the Environmental Forensic application of PSIA, the results of which are certain to give some insight into the biogeochemical cycling of contaminant organic compounds released to the environment.

在这里，我们提出了一个“飞跃”的应用位置特定的同位素分析环境法医学，一个主题，有一个很大的未开发的潜在的生物化学/生物降解研究。化合物特异性同位素分析（CSIA）是环境法医学中一种较新的方法。PSIA可以揭示/解开CSIA已经打开的问题，并超越我们对环境中污染物命运的理解。同位素分馏仅限于与限速生物降解步骤相关的污染物分子中的位点或键的反应。这些分馏效应在“全分子”CSIA中被非反应碳原子的存在所稀释。然而，分子内同位素比值对这种分馏效应敏感，可用于确定降解途径和机制。Kalin教授的EPSRC资助的平台补助金的资源，因此提供了“基线现实世界”访问网站和样本的建议“投机工程”的研究，从而使这里提出的研究只专注于解决问题：PSIA对环境法医应用有用吗？目前的惯例会说PSIA对于“真实的世界”是不切实际的，但是我们对此提出质疑，并坚信这种方法的潜力。有许多其他领域的研究，可能会受益于一个协调一致的投机性研究工作的环境法医应用PSIA，其结果是肯定会给一些深入了解污染物的有机化合物释放到环境中的地球化学循环。

项目成果

Can polychlorinated biphenyl (PCB) signatures and enantiomer fractions be used for source identification and to age date occupational exposure?

• DOI: 10.1016/j.envint.2015.04.006
• 发表时间: 2015-08
• 期刊: Environment international
• 影响因子: 11.8
• 作者: D. Megson;J. Focant;D. Patterson;M. Robson;M. Lohan;P. Worsfold;S. Comber;R. Kalin;E. Reiner-E.-Reine

On-line high-precision carbon position-specific stable isotope analysis: A review

• DOI: 10.1016/j.trac.2015.07.010
• 发表时间: 2016-02
• 期刊: Trends in Analytical Chemistry
• 作者: C. Gauchotte-Lindsay;S. Turnbull