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Electronic Sonotweezers: Particle Manipulation with Ultrasonic Arrays

电子声镊：利用超声波阵列进行粒子操纵

基本信息

批准号：
EP/G012067/1
负责人：
Bruce Drinkwater
金额：
$ 114.32万
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FG012067%2F1
关键词：
Electronic Sonotweezers Particle Manipulation Ultrasonic

项目摘要

We have carefully planned this research programme to pioneer a wholly new capability in ultrasonic particle manipulation to allow electronic sonotweezers to take their place alongside optical tweezers, dielectrophoresis and other techniques in the present and future particle manipulation toolkit.Following end-user demand, particle manipulation is a rapidly growing field, notably applied to the life sciences, with emerging applications in analysis and sorting, measurement of cell forces and tissue engineering. Existing devices have valuable capabilities but also limits in terms of forces that can be produced and measured, particle sizes that can be handled, their range of compatible buffer characteristics and sensitivity to heating, and suitability for integration with sensors in low cost devices. Key to our programme is the concept of dynamic potential energy landscapes and the established ability of ultrasound to create such landscapes, potentially to generate forces under electronic / computer control. Our principal technical aim is to exploit this in integrated sonotweezers to apply and measure larger forces over longer length scales, extend micromanipulation to larger particles, and demonstrate this in pathfinder applications in life sciences.To achieve our aims, we have already carried out successful feasibility studies and brought together an outstanding multidisciplinary team of investigators including internationally established members, some of the UK's most exciting young scientists and engineers, and appropriate overseas collaborators. Such a team is a prerequisite for what we recognise as a challenging, highly complex, densely interlinked programme. Over its four years, with strong management and built-in research flexibility, we will explore key areas of science, technology and applications to create and demonstrate electronic sonotweezers. Throughout the work, there will be parallel activity in understanding of physical principles, modelling and design, state-of-the-art fabrication, sensor integration, and applications testing.

我们精心策划了这项研究计划，以开创一种全新的超声波粒子操纵能力，使电子声镊与光镊，介电泳和其他技术一起在现在和未来的粒子操纵工具包中占据一席之地。随着最终用户的需求，粒子操纵是一个快速增长的领域，特别是应用于生命科学，在分析和分选方面有着新兴的应用，测量细胞力和组织工程。现有的装置具有有价值的能力，但在可产生和测量的力、可处理的颗粒尺寸、它们的相容缓冲特性和对加热的敏感性的范围以及与低成本装置中的传感器集成的适用性方面也有限制。我们计划的关键是动态势能景观的概念和超声波创建这种景观的能力，可能在电子/计算机控制下产生力量。我们的主要技术目标是在集成超声镊中利用这一点，在更长的长度尺度上施加和测量更大的力，将显微操作扩展到更大的颗粒，并在生命科学的开拓者应用中证明这一点。为了实现我们的目标，我们已经进行了成功的可行性研究，并汇集了一个杰出的多学科研究团队，包括国际知名的成员，一些英国最令人兴奋的年轻科学家和工程师，以及适当的海外合作者。这样一个团队是我们认为是一个具有挑战性的，高度复杂的，紧密相连的计划的先决条件。在四年的时间里，凭借强大的管理和内置的研究灵活性，我们将探索科学，技术和应用的关键领域，以创建和展示电子声镊。在整个工作中，将有物理原理，建模和设计，最先进的制造，传感器集成和应用测试的理解平行活动。