VITAMIN A IN GROWTH AND DEVELOPMENT
生长和发育中的维生素 A
基本信息
- 批准号:3311058
- 负责人:
- 金额:$ 2.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-09-01 至 1989-03-31
- 项目状态:已结题
- 来源:
- 关键词:RNA all trans retinol analytical method autoradiography binding proteins cell differentiation cell nucleus developmental nutrition electron microscopy gene expression genetic transcription glucocorticoids growth /development histochemistry /cytochemistry immunochemistry intestinal mucosa laboratory rat liver lung mature animal molecular pathology newborn animals nucleic acid hybridization nucleoproteins nutrition related tag postnatal growth disorder protein sequence radioimmunoassay radiotracer receptor retinoate testis tissue /cell culture vitamin A deficiency vitamin metabolism
项目摘要
The objective of proposed in vivo as well as in vitro nutritional and
biochemical research is to continue to define the mechanisms(s) of action
of the important micronutrient vitamin A at the molecular level in organs
other than the eye. The participation in the mode of vitamin action of two
distinct specific intracellular cytoplasmic binding proteins for retionl
(vitamin A alcohol) and for retinoic acid (vitamin A acid) purified to
homogeneity from rat liver and testis will receive particular attention.
In vitro studies are proposed how retinol and retinoic acid bound to their
respective binding proteins interact with the cell nucleus changing thereby
the genomic expression underlying cell differentiation. The in vivo
studies are directed towards the elucidation of factor which regulate the
levels of these binding proteins in various organs in adult and in neonatal
rats. To this end sensitive radioimmunoassys developed for both binding
proteins will be utilized.
提出的目标是在体内以及体外营养和
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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FRANK CHYTIL其他文献
FRANK CHYTIL的其他文献
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{{ truncateString('FRANK CHYTIL', 18)}}的其他基金
REPRODUCTIVE BIOLOGY, BIOCHEMISTRY AND ENDOCRINOLOGY
生殖生物学、生物化学和内分泌学
- 批准号:
2195050 - 财政年份:1975
- 资助金额:
$ 2.59万 - 项目类别:
REPRODUCTIVE BIOLOGY, BIOCHEMISTRY AND ENDOCRINOLOGY
生殖生物学、生物化学和内分泌学
- 批准号:
3538799 - 财政年份:1975
- 资助金额:
$ 2.59万 - 项目类别:
REPRODUCTIVE BIOLOGY, BIOCHEMISTRY, AND ENDOCRINOLOGY
生殖生物学、生物化学和内分泌学
- 批准号:
3538806 - 财政年份:1975
- 资助金额:
$ 2.59万 - 项目类别:
REPRODUCTIVE BIOLOGY, BIOCHEMISTRY AND ENDOCRINOLOGY
生殖生物学、生物化学和内分泌学
- 批准号:
2195048 - 财政年份:1975
- 资助金额:
$ 2.59万 - 项目类别:
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