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ENDOCRINOLOGY OF THE TESTIS--FETAL AND NEONATAL ASPECTS

ENDOCRINOLOGY OF THE TESTIS--FETAL AND NEONATAL ASPECTS
睾丸内分泌学——胎儿和新生儿方面
批准号:
3313366
负责人:
DWIGHT W WARREN
金额:
$12.46万
依托单位国家:
美国
项目类别:
财政年份:
1982
资助国家:
美国
项目状态:
已结题
起止时间:
1982-07-01 至 1990-08-31

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中文摘要
翻译
成人睾丸的内分泌学已经被许多人研究过
英文摘要
The endocrinology of the adjult testis has been studied by many investigators over a period of several decades. Regulation of the adult testis by pituitary hormones acting through plasma membrane receptors on the Leydig cell, activation of adenyl cyclase with the resultant production of 3', 5'-cyclic adenosine monophosphate (cAMP), and ultimate steroidogenesis has received much attention. In addition, steroidogenic pathways for androgen production have been exhaustively explored. While some studies have inquired into these aspects of the endocrinology of the fetal and neonatal testis, the parameters of Leydig cell regulation and secondarily, pituitary gland function as it relates to the Leydig cell are not nearly as well understood as in the adult. In order to better understand the endocrinology of the fetal and neonatal rat testis and how these organs differ from each other and the adult rat testis, an experimental plan has been devised which will: 1) Quantify prolactin and FSH receptor content during development in the fetal and neonatal rat testis; 2) Determine if the Leydig cell receptors for LH and prolactin in fetal and/or neonatal rat testes are subject to homologous or heterologous regulation, as has been observed in the adult by both in vivo and in vitro culture system techniques; 3) Quantify the percentage of spare LH receptors in the fetal and neonatal rat testis and assess the sensitivity of these organs to stimulation byLH; 4) Assess the coupling of the LH binding to its receptor, cAMP generation, testosterone and 5Alpha-reduced androgen synthesis in the fetal and neonatal rat testis; 5) Determine the responsivity of the fetal pituitary gland to stimulaion by GnRH; 6) Determine if the fetal pituitary gland regulates LH receptors by in vivo regulation of LH and prolactin secretion. By assessing these functions in the fetal and neonatal rat testis and comparing them with the same parameters in the adult testis, we will be able to better understand the overall continuum of male reproductive endocrinology and the events which contribute to attaining reporductive maturity in the male.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Development of transmembrane signaling in the fetal rat Leydig cell.
胎鼠 Leydig 细胞中跨膜信号传导的发展。
DOI: 10.1002/j.1939-4640.1989.tb00147.x
发表时间: 1989
期刊: Journal of andrology
影响因子: --
作者: [Warren,DW]
通讯作者: Warren,DW
Development of the inhibitory guanine nucleotide-binding regulatory protein in the rat testis.
大鼠睾丸中抑制性鸟嘌呤核苷酸结合调节蛋白的开发。
DOI: 10.1095/biolreprod40.6.1208
发表时间: 1989
期刊: Biology of reproduction
影响因子: 3.6
作者: [Warren,DW]
通讯作者: Warren,DW
Quantitative assessment of the biological effects of follicle regulatory protein on dihydrotestosterone-maintained spermatogenesis in hypophysectomized rat.
卵泡调节蛋白对垂体切除大鼠二氢睾酮维持精子发生的生物学效应的定量评估。
DOI: 10.1002/ar.1092240408
发表时间: 1989
期刊: The Anatomical record
影响因子: --
作者: [Ahmad,N, Toppari,J, diZerega,GS, Warren,DW]
通讯作者: Warren,DW
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
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