ENDOCRINOLOGY OF THE TESTIS--FETAL AND NEONATAL ASPECTS
ENDOCRINOLOGY OF THE TESTIS--FETAL AND NEONATAL ASPECTS
批准号:
3313366
负责人:
DWIGHT W WARREN
金额:
$12.46万
依托单位国家:
美国
项目类别:
财政年份:
1982
资助国家:
美国
项目状态:
已结题
起止时间:
1982-07-01 至 1990-08-31
关键词:
G protein Leydig cells binding proteins cell membrane cyclic AMP electron microscopy embryo /fetus glucocorticoids growth /development guanosine triphosphate hormone receptor hormone regulation /control mechanism laboratory mouse laboratory rabbit laboratory rat luteinizing hormone newborn animals organ culture pregnancy progestins prolactin radiotracer steroid hormone biosynthesis testis testosterone vasopressins
中文摘要
睾丸的内分泌学已经被很多人研究过了。
调查人员花了几十年的时间。对成年人的监管
垂体激素通过质膜受体作用于睾丸
间质细胞,腺苷环化酶的激活及其产物
3‘,5’-环磷酸腺苷(CAMP),并最终
类固醇的发生受到了极大的关注。此外,类固醇激素生成
产生雄激素的途径已经被彻底探索过了。而当
一些研究探讨了糖尿病患者内分泌学的这些方面。
胎儿和新生儿睾丸,间质细胞调节参数和
其次,垂体腺的功能与间质细胞有关
远不如成年人理解得好。为了更好地
了解胎儿和新生大鼠睾丸的内分泌学以及如何
这些器官彼此不同,成年大鼠的睾丸和
已经制定了实验计划,它将:1)定量催乳素和
FSH受体在胚胎和新生大鼠发育过程中的含量
2)测定睾丸间质细胞对黄体生成素和催乳素的受体
胎儿和/或新生大鼠睾丸受同源或异源影响
在体内和体外观察到的对成人的调节
培养体系技术;3)测定空腹黄体生成素百分比
胎鼠和新生大鼠睾丸中的受体及其敏感性
这些器官对促黄体生成素的刺激;4)评估促黄体生成素的偶联
与其受体结合、cAMP生成、睾酮和5α-还原
胎儿和新生大鼠睾丸中雄激素的合成;5)测定
胎儿脑下垂体对促性腺激素释放激素刺激的反应性
确定胎儿脑下垂体是否通过体内调节黄体生成素受体
黄体生成素和催乳素分泌的调节。通过评估以下各项功能
胎鼠和新生大鼠睾丸组织的比较
成人睾丸的参数,我们将能够更好地理解
男性生殖内分泌学的整体连续体和
有助于男性达到报告性成熟。
英文摘要
The endocrinology of the adjult testis has been studied by many
investigators over a period of several decades. Regulation of the adult
testis by pituitary hormones acting through plasma membrane receptors on
the Leydig cell, activation of adenyl cyclase with the resultant production
of 3', 5'-cyclic adenosine monophosphate (cAMP), and ultimate
steroidogenesis has received much attention. In addition, steroidogenic
pathways for androgen production have been exhaustively explored. While
some studies have inquired into these aspects of the endocrinology of the
fetal and neonatal testis, the parameters of Leydig cell regulation and
secondarily, pituitary gland function as it relates to the Leydig cell are
not nearly as well understood as in the adult. In order to better
understand the endocrinology of the fetal and neonatal rat testis and how
these organs differ from each other and the adult rat testis, an
experimental plan has been devised which will: 1) Quantify prolactin and
FSH receptor content during development in the fetal and neonatal rat
testis; 2) Determine if the Leydig cell receptors for LH and prolactin in
fetal and/or neonatal rat testes are subject to homologous or heterologous
regulation, as has been observed in the adult by both in vivo and in vitro
culture system techniques; 3) Quantify the percentage of spare LH
receptors in the fetal and neonatal rat testis and assess the sensitivity
of these organs to stimulation byLH; 4) Assess the coupling of the LH
binding to its receptor, cAMP generation, testosterone and 5Alpha-reduced
androgen synthesis in the fetal and neonatal rat testis; 5) Determine the
responsivity of the fetal pituitary gland to stimulaion by GnRH; 6)
Determine if the fetal pituitary gland regulates LH receptors by in vivo
regulation of LH and prolactin secretion. By assessing these functions in
the fetal and neonatal rat testis and comparing them with the same
parameters in the adult testis, we will be able to better understand the
overall continuum of male reproductive endocrinology and the events which
contribute to attaining reporductive maturity in the male.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Development of transmembrane signaling in the fetal rat Leydig cell.
胎鼠 Leydig 细胞中跨膜信号传导的发展。
DOI:
10.1002/j.1939-4640.1989.tb00147.x
发表时间:
1989
期刊:
Journal of andrology
影响因子:
--
作者:
[Warren,DW]
通讯作者:
Warren,DW
Development of the inhibitory guanine nucleotide-binding regulatory protein in the rat testis.
大鼠睾丸中抑制性鸟嘌呤核苷酸结合调节蛋白的开发。
DOI:
10.1095/biolreprod40.6.1208
发表时间:
1989
期刊:
Biology of reproduction
影响因子:
3.6
作者:
[Warren,DW]
通讯作者:
Warren,DW
Quantitative assessment of the biological effects of follicle regulatory protein on dihydrotestosterone-maintained spermatogenesis in hypophysectomized rat.
卵泡调节蛋白对垂体切除大鼠二氢睾酮维持精子发生的生物学效应的定量评估。
DOI:
10.1002/ar.1092240408
发表时间:
1989
期刊:
The Anatomical record
影响因子:
--
作者:
[Ahmad,N, Toppari,J, diZerega,GS, Warren,DW]
通讯作者:
Warren,DW
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
-
批准号:2019799
-
项目类别:
-
资助金额:$29.98万
-
财政年份:1994
-
负责人:DWIGHT W WARREN
-
依托单位:
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
-
批准号:2163031
-
项目类别:
-
资助金额:$27.57万
-
财政年份:1994
-
负责人:DWIGHT W WARREN
-
依托单位:
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
-
批准号:2163032
-
项目类别:
-
资助金额:$28.8万
-
财政年份:1994
-
负责人:DWIGHT W WARREN
-
依托单位:
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
-
批准号:2711066
-
项目类别:
-
资助金额:$32.5万
-
财政年份:1994
-
负责人:DWIGHT W WARREN
-
依托单位:
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
-
批准号:2545860
-
项目类别:
-
资助金额:$31.25万
-
财政年份:1994
-
负责人:DWIGHT W WARREN
-
依托单位:
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
-
批准号:3266838
-
项目类别:
-
资助金额:$8.15万
-
财政年份:1993
-
负责人:DWIGHT W WARREN
-
依托单位:
SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
-
批准号:3509755
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1992
-
负责人:DWIGHT W WARREN
-
依托单位:
ENDOCRINOLOGY OF THE TESTIS--FETAL AND NEONATAL ASPECTS
-
批准号:3313365
-
项目类别:
-
资助金额:$11.84万
-
财政年份:1982
-
负责人:DWIGHT W WARREN
-
依托单位:
ENDOCRINOLOGY OF THE TESTIS--FETAL AND NEONATAL ASPECTS
-
批准号:3313362
-
项目类别:
-
资助金额:$12.04万
-
财政年份:1982
-
负责人:DWIGHT W WARREN
-
依托单位:
海外基金