NEUROENDOCRINE REGULATION OF EPISODIC LH RELEASE

间歇性 LH 释放的神经内分泌调节

• 批准号: 3314755
• 负责人: ROBERT V GALLO
• 金额: $ 21.82万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3314755
• 关键词: antidromic impulse; blood chemistry; brain; catecholamines; dorsal raphe nucleus; electrostimulus; estradiol; estrogens; estrus; histology; neural information processing; neuroendocrine system; ovariectomy; pituitary gland; progesterone; prosencephalon; radioimmunoassay; radiotracer; scintillation spectrometry; serotonin; sex cycle; ultracentrifugation

The overall objective of this research program is to clarify the role of the brain and endocrine stimuli in the regulation of pulsatile LH release. Specific areas of investigation will include the influence of various CNS areas on pulsatile LH release, the role of neurotransmitters such as serotonin or dopamine in mediating any observed effects, the parameters of pulsatile LH release affected, i.e., LH interpulse interval or LH pulse magnitude, and possible modification of brain serotoninergic function by estrogen.

该研究计划的总体目标是阐明 大脑和内分泌刺激对脉动 LH 释放的调节。 具体的 调查领域将包括各个中枢神经系统区域对 脉冲式 LH 释放，神经递质（如血清素或）的作用 多巴胺介导任何观察到的效应，脉动 LH 参数 受影响的释放，即 LH 脉冲间隔或 LH 脉冲幅度，以及 雌激素可能改变大脑的血清素能功能。