NEUROENDOCRINE REGULATION OF EPISODIC LH RELEASE

这项研究计划的总体目标是澄清 脑和内分泌刺激对黄体生成素脉冲性释放的调节作用。特定的 调查的领域将包括中枢神经各个区域对 脉动性促黄体生成素释放，神经递质的作用，如5-羟色胺或 多巴胺在调节任何观察到的效应中的作用，搏动性促黄体生成素参数 受影响的释放，即，LH脉冲间期或LH脉冲幅，以及 雌激素对大脑5-羟色胺能功能的可能改变。

The overall objective of this research program is to clarify the role of the brain and endocrine stimuli in the regulation of pulsatile LH release. Specific areas of investigation will include the influence of various CNS areas on pulsatile LH release, the role of neurotransmitters such as serotonin or dopamine in mediating any observed effects, the parameters of pulsatile LH release affected, i.e., LH interpulse interval or LH pulse magnitude, and possible modification of brain serotoninergic function by estrogen.