Microfluidic reactors for the rapid synthesis of 11C-labelled molecules for PET imaging

在这个项目中，我们的目标是开发和利用一种新的技术，快速11 C同位素标记的生物医学感兴趣的分子。更具体地说，我们建议开发一种微流控反应系统，用于使用11 CO作为放射性核素源快速标记靶分子。在该装置中，我们提出：a）一个组件（基于过渡金属络合物）的11 CO的预浓缩;和B）固体负载的钯催化剂，以加速该气体与特定的基板的反应，用于合成生物医学感兴趣的标记分子。这两个阶段的方法将有助于克服目前阻碍11 CO标记方法的两个主要缺点，即反应性差和低浓度的CO。我们的最终目标是有一个使能技术，在15分钟内进行PET成像所需的所有步骤，包括a）11 CO的预浓缩; B）催化反应，以将11 CO结合到目标分子上; d）将标记的探针用于PET成像。

In this project we aim to develop and exploit a new technology for the fast 11C isotopic labelling of molecules of biomedical interest. More specifically we propose to develop a microfluidic reaction system for the rapid labelling of target molecules using 11CO as a radionuclide source. In this device we propose to have: a) one component (based on transition metal complexes) for the pre-concentration of 11CO; and b) a solid-supported palladium catalyst to accelerate the reaction of this gas with specific substrates for the synthesis of labelled molecules of biomedical interest. This two-stage approach will help to overcome the 2 major drawbacks that currently hinder 11CO labelling methodologies, namely poor reactivity and low concentrations of CO. Our final aim is to have an enabling technology to perform all the steps required for PET imaging with 11C-labelled probes within 15min, including a) pre-concentration of 11CO; b) catalytic reactions to incorporate 11CO onto the target molecule; c) purify labelled species; d) use the labelled probe for PET imaging.