ANDROGENS AND ANDROGEN RECEPTORS IN MALE INFERTILITY

睾丸内的间质细胞产生的睾酮，作为对 由脑下垂体分泌的促黄体激素，是 被认为是生殖细胞发育的重要调节因子。我们建议 探讨睾丸雄激素异常或 雄激素受体与某些生精小管功能障碍有关 各种形式的男性不育。 睾丸类固醇分泌将通过重复的性腺静脉进行研究 精索静脉曲张相关性不育症患者抽样调查结果分析 与促性腺激素分泌有关。体内存在的雄激素 将用放射免疫分析法研究人类睾丸的生精小管 方法采用高效液相色谱分离。 将研究人类生精小管中的雄激素受体 食蟹猴。最后，Sertoli细胞丰富的培养来自 青春期前亚人类灵长类动物的睾丸将被建立并 本课程将探讨雄激素代谢和受体结合。 因为特发性男性不育是一种常见的疾病，没有统一的 有效的治疗，这些研究对临床医生和 生理学，内分泌学，生物化学领域的研究人员， 泌尿科和妇科。

Testosterone produced by Leydig cells within the testis, in response to stimulation by Luteinizing Hormone secretion by the pituitary gland, is believed to be an important regulator of germ cell development. We propose to explore the hypothesis that abnormalities of testicular androgens or androgen receptors are related to seminiferous tubule dysfunction in some forms of male infertility. Testicular steroid secretion will be studied by repetitive gonadal vein sampling to men with varicocele-related infertility and the findings related to gonadotropin secretion. The androgens present in the seminiferous tubules of human testis will be studied by radioimmunoassay methods following separation by high performance liquid chromatography. Androgen receptors will be studied in seminiferous tubules from humans and cynomolgus monkeys. Finally, Sertoli cell-enriched cultures derived from the testes of prepubertal subhuman primates will be established and androgen metabolism and receptor binding will be explored. Because idiopathic male infertility is a common disorder with no uniformly effective treatment, these studies are of importance to clinicians and investigators in the fields of physiology, endocrinology, biochemistry, urology, and gynecology.