NONSURGICAL TREATMENT OF CONGENITAL HEART DISEASE

先天性心脏病的非手术治疗

• 批准号: 3334460
• 负责人: HENRY R WAGNER
• 金额: $ 10.3万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1987-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3334460
• 关键词: biomaterials; cineangiocardiography; clinical biomedical equipment; congenital heart disorder; congenital heart septum defect; disease /disorder model; heart catheterization; heart prosthesis; human middle age (35-64); human subject; newborn animals; newborn human (0-6 weeks); patent ductus arteriosus

The use of the cardiac catheter as a tool for laboratory and clinical investigation has opened a new era in the understanding of many physiologic and clinical aspects of cardiovascular function and disease. This has been particularly true in the field of congenital heart disease. There have been a few attempts to perform therapeutic procedures using cardiac catheterization. Our technique to produce a palliative atrial septostomy using a balloon-tipped catheter has been one of the most productive areas of this type of study. We have also had clinical experience in transcatheter closure of atrial septal defects, and in transcatheter closure of patent ductus arteriosus. We propose to continue our experiments on 1) using the catheter as a means of introducing detachable prostheses for closure of atrial septal defects and patent ductus arteriosus; 2) developing self-seating prostheses for transcatheter closure of ventricular septal defects; 3) expansion of the clinical application of these methods.

心导管作为实验室和临床工具的应用 研究为理解许多生理学现象开辟了一个新纪元。 以及心血管功能和疾病的临床方面。 这是 在先天性心脏病领域尤其如此。 已经 已经有一些尝试使用心脏瓣膜进行治疗程序， 漂浮导管 我们的姑息性房间隔造口术技术 使用球囊导管已经成为最有效的领域之一 这种类型的研究。 我们也有临床经验， 房间隔缺损的经导管封堵术， 动脉导管未闭闭合术。 我们建议继续我们的 实验1）使用导管作为引入可脱性的手段 用于房间隔缺损和未闭导管闭合的假体 动脉; 2）开发用于经导管闭合的自固定假体 扩大了室间隔缺损的临床应用 这些方法。

项目成果

Interventional cardiac catheterization in congenital heart disease.

先天性心脏病的介入心导管检查。

• 发表时间: 1985
• 期刊: Cardiovascular clinics
• 作者: Rashkind,WJ

Nonsurgical closure of patent ductus arteriosus: clinical application of the Rashkind PDA Occluder System.

动脉导管未闭的非手术闭合：Rashkind PDA 封堵器系统的临床应用。

• DOI: 10.1161/01.cir.75.3.583
• 发表时间: 1987
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Rashkind,WJ;Mullins,CE;Hellenbrand,WE;Tait,MA
• 通讯作者: Tait,MA