EFFECT OF DIET ON SEXUAL MATURATION AND PUBERTY

饮食对性成熟和青春期的影响

• 批准号: 3318863
• 负责人: SUSAN M SCHWARTZ
• 金额: $ 12.93万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3318863
• 关键词: Macaca mulatta; animal puberty; anorexia nervosa; basal metabolism; body composition; caloric dietary content; developmental nutrition; dietary lipid; estradiol; exercise; female; glucose; hormone metabolism; insulin; menstrual cycle disorder; neuroendocrine system; nutrition related tag; ovulation; prolactin; reproductive development; seasons; somatotropin; steroid hormone

It is well established that nutritional status plays an important role in the onset of puberty. It has been proposed that changes in the metabolic state of the maturing animal may directly influence neuroendocrine factors associated with the timing of puberty. We propose that diet, in particular, a high fat diet, through metabolic and endocrine changes may directly influence sexual maturation and the timing of first ovulation, independent of changes in overall growth. We will examine the effect of different diets (high fat-high protein, high fat-low protein, high carbohydrate-high protein and standard high protein chow) on growth and sexual maturation and the timing of first ovulation using the prepubertal rhesus female, housed outdoors, as a model. Starting at 12 mo of age, we will examine the effects of diet on: (a) somatic growth, reflected in body weight, crown-rump lengths, percent body fat and adipose cellularity; (b) growth related endocrine factors including growth hormone (GH), somadomedin-C (SM-C), prolactin, glucose, and insulin; (c) food intake and energy expenditure, reflected in basal metabolic rate, and (d) possible seasonal patterns in growth, feeding and energy expenditure. The effect of these regulatory changes in relation to sexual maturation will be examined by monitoring maturational increases in gonadal steroids and gonadotropin secretion. Developmental and diet-induced changes in gonadal status in relation to changes in the metabolic and reproductive state (insulin, GH, SM-C, LH) will be examined by measuring ovarian steroid concentrations and the major pathways for estradiol metabolism. Finally, we will examine more closely effects of diet on metabolic factors (insulin, free fatty acids, glucagon, large neutral amino acids) by measuring concentrations before and after administration of a glucose load (iv glucose tolerance test). This project will provide new information on the effects of diet and metabolism on sexual maturation and the timing of first ovulation.

众所周知，营养状况在 青春期的发作。 已经提出了代谢的变化 成熟动物的状态可能直接影响神经内分泌因素 与青春期的时机有关。 我们建议饮食， 特别是，通过代谢和内分泌变化，高脂饮食可能 直接影响性成熟和第一次排卵的时机， 独立于整体增长的变化。 我们将研究 不同的饮食（高脂肪高蛋白，高脂肪低蛋白，高蛋白 在生长和 性成熟和使用青春期前排卵的时机 恒河雌性，在户外，作为榜样。 从12月开始，我们 将检查饮食对：（a）体现在体内的躯体生长的影响 体重，冠状长度，体内脂肪百分比和脂肪细胞； （b） 与生长相关的内分泌因子，包括生长激素（GH）， somadosedomedomedy-c（SM-C），催乳素，葡萄糖和胰岛素； （c）食物摄入量和 能量支出，反映在基础代谢率中，并且可能 生长，喂养和能量消耗的季节性模式。 效果 这些与性成熟有关的调节变化将进行检查 通过监测性腺类固醇和促性腺激素的成熟增加 分泌。 发育和饮食引起的性腺状态变化 与代谢和生殖状态的变化有关（胰岛素，GH，， SM-C，LH）将通过测量卵巢类固醇浓度和 雌二醇代谢的主要途径。 最后，我们将检查更多 饮食对代谢因子的紧密影响（胰岛素，游离脂肪酸， 胰高血糖素，大型中性氨基酸）通过测量之前和 施用葡萄糖负荷后（IV葡萄糖耐量测试）。 这 项目将提供有关饮食和代谢影响的新信息 关于性成熟和第一次排卵的时间。