Self-assembling virus-like particles

自组装病毒样颗粒

• 批准号: EP/G043302/1
• 负责人: Bruce Turnbull
• 金额: $ 62.43万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG043302%2F1
• 关键词: Self; assembling; virus; like; particles

Nature has evolved proteins that can spontaneously self-assemble to create complex structures such as virus particles and molecular motors. These capsules and molecular machines typically have sizes of 10-100 nm and thus constitute ideal building blocks for nanotechnology. The fields of bionanoscience and synthetic biology are based on the concept that by combining biological building blocks with synthetic molecules it will be possible to construct novel nano-scale objects and machines that can do useful work. The applications of bionanoscience can range from targeted drug/gene delivery for healthcare to making nano-patterned surfaces for molecular electronics. In this project we will develop new strategies to self-assemble virus-like particles using naturally occurring proteins which will be linked together by synthetic molecules.

自然界已经进化出可以自发自组装的蛋白质，以创造复杂的结构，如病毒颗粒和分子马达。这些胶囊和分子机器通常具有10-100 nm的尺寸，因此构成了纳米技术的理想构建模块。生物纳米科学和合成生物学领域基于这样的概念，即通过将生物构建模块与合成分子相结合，可以构建可以做有用工作的新型纳米尺度物体和机器。生物纳米科学的应用范围可以从医疗保健的靶向药物/基因递送到分子电子学的纳米图案表面。在这个项目中，我们将开发新的策略，使用天然存在的蛋白质自组装病毒样颗粒，这些蛋白质将通过合成分子连接在一起。

项目成果

A protein-based pentavalent inhibitor of the cholera toxin B-subunit.

• DOI: 10.1002/anie.201404397
• 发表时间: 2014-08-04
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Branson, Thomas R.;McAllister, Tom E.;Garcia-Hartjes, Jaime;Fascione, Martin A.;Ross, James F.;Warriner, Stuart L.;Wennekes, Tom;Zuilhof, Han;Turnbull, W. Bruce
• 通讯作者: Turnbull, W. Bruce

Mechanistic studies on a sulfoxide transfer reaction mediated by diphenyl sulfoxide/triflic anhydride.

• DOI: 10.1002/chem.201102861
• 发表时间: 2012-03-05
• 期刊: CHEMISTRY-A EUROPEAN JOURNAL
• 影响因子: 4.3
• 作者: Fascione, Martin A.;Adshead, Sophie J.;Mandal, Pintu K.;Kilner, Colin A.;Leach, Andrew G.;Turnbull, W. Bruce
• 通讯作者: Turnbull, W. Bruce

Stereoselective glycosylations using oxathiane spiroketal glycosyl donors.

• DOI: 10.1016/j.carres.2011.07.020
• 发表时间: 2012-02
• 期刊: Carbohydrate research
• 影响因子: 3.1
• 作者: M. Fascione;Nicola J. Webb;Colin A. Kilner;Stuart L. Warriner;W. Bruce Turnbull

Mechanistic Investigations into the Application of Sulfoxides in Carbohydrate Synthesis.

• DOI: 10.1002/chem.201503504
• 发表时间: 2016-03-14
• 期刊: Chemistry (Weinheim an der Bergstrasse, Germany)
• 作者: Fascione MA;Brabham R;Turnbull WB
• 通讯作者: Turnbull WB

Multivalent glycoconjugates as anti-pathogenic agents.

• DOI: 10.1039/c2cs35408j
• 发表时间: 2013-06-07
• 期刊: Chemical Society reviews
• 影响因子: 46.2
• 作者: Bernardi A;Jiménez-Barbero J;Casnati A;De Castro C;Darbre T;Fieschi F;Finne J;Funken H;Jaeger KE;Lahmann M;Lindhorst TK;Marradi M;Messner P;Molinaro A;Murphy PV;Nativi C;Oscarson S;Penadés S;Peri F;Pieters RJ;Renaudet O;Reymond JL;Richichi B;Rojo J;Sansone F;Schäffer C;Turnbull WB;Velasco-Torrijos T;Vidal S;Vincent S;Wennekes T;Zuilhof H;Imberty A
• 通讯作者: Imberty A