Kruppel-like factors and the methylome

该项目旨在验证KLF/SP家族转录因子部分通过与DNA中甲基化胞嘧啶核苷酸的动态相互作用而起作用的假设。这是它们作为重编程先驱因子的功能和协调分化和器官发生的能力的基础。相反，甲基化状态的动态变化通过KLF/SP家族蛋白作为特异性效应物的募集，参与或脱离基因组中的新调控元件。这个项目将解决一个新的遗传学范例，这可能是发展的基础。

This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.