PROSPEcT: Ecotoxicology test protocols for representative nanomaterials in support of the OECD sponsorship programme

前景：支持经合组织赞助计划的代表性纳米材料的生态毒理学测试方案

• 批准号: EP/G043140/1
• 负责人: Tamara Susan Galloway
• 金额: $ 60.81万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG043140%2F1
• 关键词: PROSPEcT; Ecotoxicology; test; protocols; representative

The proposed research forms an integral part of the PROSPEcT LINK project, initiated through the 'Nanoscience through Engineering to Application' programme. The project aims to provide a direct contribution to the global safety assessment of nanomaterials described by the OECD Working Party on Manufactured Nanomaterials (WPMN). The LINK project will develop essential and seminal test methods and data on two agreed nanomaterials that are of particular commercial relevance to the UK. The project will innovate the scientific foundations for adapting or creating test methods that enable the ecotoxicological hazard assessment of nanomaterials. Both particles (i.e. CeO2 and ZnO) are part of a list of 14 nanomaterials, identified as commercially relevant to the global economic impact of nanotechnology. Furthermore, the development of methods to characterize CeO2 and ZnO nanomaterials in concert with parallel and coordinated development for other nanomaterials across the OECD testing program will enablethe future establishment of QSARs (Quantitative Structure Activity Relationships) for predictive safety evaluations of novel nanomaterials.The resulting scientific advancement will help to secure an economic future for the commercialisation of nanotechnologies in and by the UK and provide crucial UK leadership and information to the OECD's global programme on nanomaterials safety assessment.

拟议的研究是 PROSPECT LINK 项目的一个组成部分，该项目是通过“从工程到应用的纳米科学”计划发起的。该项目旨在为经合组织制造纳米材料工作组 (WPMN) 描述的纳米材料全球安全评估提供直接贡献。 LINK 项目将为两种商定的纳米材料开发基本且具有开创性的测试方法和数据，这两种材料对英国具有特殊的商业意义。该项目将为适应或创建能够对纳米材料进行生态毒理学危害评估的测试方法奠定创新的科学基础。这两种颗粒（即 CeO2 和 ZnO）均属于 14 种纳米材料清单的一部分，被确定为与纳米技术的全球经济影响具有商业相关性。此外，开发表征 CeO2 和 ZnO 纳米材料的方法，与 OECD 测试计划中其他纳米材料的并行和协调开发相结合，将有助于未来建立 QSAR（定量构效关系），用于新型纳米材料的预测安全性评估。由此产生的科学进步将有助于确保纳米技术商业化的经济未来。 英国并为经合组织纳米材料安全评估全球计划提供重要的英国领导力和信息。