ULTRASONIC BIOEFFECTS ON MAMMALIAN DEVELOPMENT

拟议研究的长期目标是确定 超声波对哺乳动物的生物学影响 发展 拟议的研究分为两组，第一组是 通过以下方式评估超声暴露对卵巢的影响： 评估小鼠的植入前胚胎发育。 使用此 模型，实验已经被设计来检查不同的影响， 超声波对细胞分裂、DNA合成、蛋白质合成和 在早期出现时间调节的细胞表面分子， 胚胎 第二组实验涉及生物学 子宫内植入后对着床后胚胎的影响 暴露于超声波。 他们将测试超声波可以 对发育中的中枢神经系统造成不可逆转的损害。 已经设计了实验来表征由以下因素引起的CNS损伤： 超声暴露，以确定损伤是否可逆，以证明 阶段相关的敏感性超声，并确定是否影响 是累积的。

The long-term objectives of the research proposed are to determine the biological consequences of exposure to ultrasound on mammalian development. The studies proposed fall into two groups, the first being to evaluate the effects of ultrasound exposure of the ovary, by means of assessing preimplantation embryonic development in the mouse. Using this model, experiments have been designed to examine the effects of different levels of ultrasound on cell division, DNA synthesis, protein synthesis and the appearance of temporally-regulated cell surface molecules in the early embryo. The second group of experiments is concerned with the biological consequences to the post-implantation embryo following intrauterine exposure to ultrasound. They will test the hypothesis that ultrasound can cause irreversible damage to the developing central nervous system. Experiments have been designed to characterize CNS damage resulting from ultrasound exposure, to determine if damage is reversible, to demonstrate stage-related susceptibility to ultrasound and to determine whether effects are cumulative.