EFFECTS OF EXERCISE ON LACTATION PERFORMANCE IN HUMANS

运动对人类哺乳表现的影响

• 批准号: 3324504
• 负责人: KATHRYN G DEWEY
• 金额: $ 15.18万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3324504
• 关键词: blood chemistry; caloric dietary content; cortisol; developmental nutrition; exercise; gestational age; growth /development; hormone metabolism; human milk; infant human (0-1 year); insulin; lactation; nutrient intake activity; nutrition related tag; oxygen consumption; prolactin; sex hormones

The postpartum period is a time when many women wish to reduce body fat, with exercise often recommended as a means to achieve this. However, concern has been raised that the energy intake of very physically active women may be inadequate for optimal breast milk production. To date, there has been no systematic research on this issue. Both lactation and exercise are known to influence levels of plasma hormones involved in carbohydrate, protein and lipid metabolism. Although increased exercise leads to higher energy requirements. these hormonal changes may promote greater efficiency in breast milk synthesis, thereby, protecting, milk production in the face of high energy expenditure. Our preliminary data comparing exercising women with sedentary women during lactation show no difference in breast milk production, despite a high energy expenditure (3169 kcal/d) in the former group. The objectives of the proposed research are: 1) to evaluate the effect of a 12-week exercise program consisting of aerobic workouts five times per week on breast milk volume and composition, and 2) to determine whether plasma hormone levels (prolactin, insulin, cortisol and T3) are modified by exercise and fluctuations in maternal body composition during the first four months of lactation. The experimental design will be to randomly assign lactating women to one of two groups: a) an exercise group (N=15), in which subjects will begin an exercise program at 7 wks postpartum, or b) a control group (N=15), in which subjects will not undertake vigorous exercise more than once per week during the study. Assessments of maternal dietary intake and activity level (3-day record), body composition (hydrostatic weighing and skinfolds), resting metabolic rate (indirect calorimetry), plasma hormone levels, breast milk volume (3-day test-weighing), milk composition (24-hr sampling) and infant growth will be made at baseline (6-7 wks) and at 12-13 and 19-20 wks postpartum. Maximum oxygen uptake (V02 max) will be measured at 6-7 and 19-20 wks as an indicator of aerobic fitness. The results of this study will be important not only from the standpoint of public health policy but also in understanding the metabolic interrelationships between maternal nutritional status, physical activity, and lactation performance.

产后期是许多女性希望瘦身的时期 肥胖，经常推荐运动作为达到这一目标的一种手段。 然而，人们已经提出了担忧，即非常多的能量摄入 体力活动的女性可能不足以获得最佳母乳 制作。到目前为止，还没有关于这方面的系统研究。 问题。 已知哺乳和锻炼都会影响血浆水平 激素参与碳水化合物、蛋白质和脂肪的代谢。 尽管增加锻炼会导致更高的能量需求。 这些荷尔蒙的变化可能会提高乳房的效率。 乳汁合成，从而保护面部产奶量 高能量消耗。我们的初步数据比较 与哺乳期久坐不动的女性一起锻炼的女性没有 母乳产量的差异，尽管能量很高 前一组的支出(3169千卡/天)。 拟议研究的目标是：1)评估 为期12周的有氧锻炼计划的效果 每周五次关于母乳的体积和成分，以及2) 以确定血浆激素水平(催乳素、胰岛素、 皮质醇和三碘甲腺原氨酸)被运动和 年前四个月的产妇身体成分 哺乳。 实验设计将随机分配哺乳期妇女 A)运动组(N=15)，其中 受试者将在产后7周开始锻炼计划，或b) 对照组(N=15)，受试者不进行 在研究期间，每周进行一次以上的剧烈运动。 对产妇膳食摄入量和活动量的评估(3天 记录)，身体成分(水压称重和皮褶)， 静息代谢率(间接量热法)、血浆激素 水平、母乳体积(3天测试称重)、牛奶成分 (24小时抽样)和婴儿生长将在基线(6-7 产后12-13周和19-20周。最大摄氧量 (最大V02)将在6-7周和19-20周测量，作为 有氧健身。 这项研究的结果将是重要的，不仅从 公共卫生政策的立场，也是在理解 母亲的营养状况与代谢之间的相互关系 体力活动和哺乳表现。