ORGANIZING THE HGI--SOCIAL IMPACT AND TECHNOLOGY DESIGN

描述(调查人员摘要)：绘制地图和排序的主动性 人类基因组正进入一个关键时期。在接下来的五年里 基因组学社区将专注于开发技术和 为实现其目标而建立的组织结构 到2005年完成序列。20世纪90年代初做出的选择 将确定测绘技术体系的基本轮廓和 对人类基因组进行测序，为21世纪奠定新的基础 世纪生物学和生物技术。设计的社会影响和 基因组计划的实施可能是巨大的。决定 今天提出了关于该公司的技术和组织结构 基因组计划将影响该计划产生的信息是如何 最终使用了这些信息并产生了社会影响。同样， 关于如何处理科学研究中固有的紧张关系的决定 这种规模的合作可能会对研究伦理产生影响 远远超出了基因组学界的范畴。因此，未来五年是 对理解具有特殊重要性的战略研究机会 基因组计划的演变及其影响。建议进行的研究 将探讨研究议程、组织设计议程和 因为基因组学社区的政策是在这个关键时期形成的 句号。系统/网络技术方法，以及 议程设置，提供了一个理论框架。这项研究将使用 对来自中国的关键线人队列的前瞻性纵向研究 社区、深度访谈和参与者仔细观察 选定的实验室。

DESCRIPTION (Investigator's Abstract): The initiative to map and sequence the human genome is entering a critical period. For the next five years, the genomics community will focus on developing technology and organizational structures for accomplishing its goal of obtaining the complete sequence by the year 2005. The choices made in the early 1990s will define the basic outline of the technological system for mapping and sequencing the human genome and lay a new groundwork for twenty first century biology and biotechnology. The social impacts of the design and implementation of the genome project are likely to be enormous. Decisions made today about the technological and organizational structure of the genome project will affect how the information the project produces is eventually used and the social impact of that information. Similarly, decisions about how to manage the tensions inherent in scientific collaboration on this scale are likely to have an effect on research ethics well beyond the genomics community. The next five years are thus a strategic research opportunity of exceptional importance for understanding the evolution of the genome project and its impact. The proposed study will explore how the agenda for research, for organizational design, and for policy of the genomics community takes shape during this critical period. The system/network approach to technology, and the concept of agenda-setting, provide a theoretical framework. The research will use a prospective, longitudinal study of a cohort of key informants from the community, in-depth interviewing, and participant observation in carefully selected laboratories.