BRAIN STEM INTEGRATION OF CHEMORECEPTOR ACTIVITY

化学感受器活性的脑干整合

• 批准号: 3336160
• 负责人: Walter St. John
• 金额: $ 12.37万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3336160
• 关键词: afferent nerve; brain stem; chemical stimulation; chemoreceptors; electrical potential; electromyography; experimental brain lesion; innervation; microelectrodes; motor neurons; neural information processing; neuroanatomy; neuroeffector; neuropharmacology; peripheral nervous system; respiratory airflow disorder; respiratory airway pressure; respiratory reflex; tongue; vagotomy

The overall goal is to describe the respiratory-related efferent activities of the hypoglossal and trigeminal nerves. These activities and those of muscles which they innervate in the oropharyngeal region have been shown to be important for maintaining upper airway patency, especially in sleep. Alterations in these neural or muscular activities or those of single hypoglossal and trigeminal neurons will be characterized in response to changes in chemoreceptor stimuli or elicitation of upper airway and/or pulmonary reflexes. Changes in these activities will also be analyzed following administration of pharmacological substances which differentially alter activities of the hypoglossal and trigeminal systems as compared to the bulbospinalphrenic system. It is hypothesized that these differential actions reflect a greater dependency for activites of hypoglossal and trigeminal neurons than bulbospinal neurons upon reticular formation processes. Data obtained will provide significant insights into mechanisms required for maintenance of upper airway patency. These data may have direct and immediate applications to the diagnosis and treatment of obstructive apneas in adults and children.

总体目标是描述呼吸相关的传出活动