BRAIN STEM INTEGRATION OF CHEMORECEPTOR ACTIVITY

总体目标是描述与呼吸相关的传出活动 舌下神经和三叉神经。这些活动以及 它们在口咽部支配的肌肉已经被证明是 对于保持上呼吸道通畅很重要，尤其是在睡眠中。 这些神经或肌肉活动的改变或单项 舌下神经元和三叉神经细胞的特征是对 上呼吸道和/或化学感受器刺激或激发的变化 肺反射。还将分析这些活动的变化 在给予不同的药理物质后 改变舌下和三叉神经系统的活动 球-脊柱-膈系统。假设这些差异 动作反映了对舌下和舌下活动的更大的依赖性 在网状结构上三叉神经神经元多于球脊髓神经元 流程。所获得的数据将提供对机制的重要见解 维持上呼吸道通畅所必需的。这些数据可能有 直接和即时地应用于诊断和治疗 成人和儿童的阻塞性呼吸暂停。

The overall goal is to describe the respiratory-related efferent activities of the hypoglossal and trigeminal nerves. These activities and those of muscles which they innervate in the oropharyngeal region have been shown to be important for maintaining upper airway patency, especially in sleep. Alterations in these neural or muscular activities or those of single hypoglossal and trigeminal neurons will be characterized in response to changes in chemoreceptor stimuli or elicitation of upper airway and/or pulmonary reflexes. Changes in these activities will also be analyzed following administration of pharmacological substances which differentially alter activities of the hypoglossal and trigeminal systems as compared to the bulbospinalphrenic system. It is hypothesized that these differential actions reflect a greater dependency for activites of hypoglossal and trigeminal neurons than bulbospinal neurons upon reticular formation processes. Data obtained will provide significant insights into mechanisms required for maintenance of upper airway patency. These data may have direct and immediate applications to the diagnosis and treatment of obstructive apneas in adults and children.