LOCAL TISSUE PERFUSION: TPD DEVELOPMENT AND MODIFICATION

局部组织灌注：TPD 开发和修改

• 批准号: 3338849
• 负责人: KENNETH R HOLMES
• 金额: $ 10.95万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-01-01 至 1989-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3338849
• 关键词: cardiovascular disorder diagnosis; clinical biomedical equipment; diagnosis quality /standard; dogs; kidney circulation; mathematical model; patient monitoring device; scanning electron microscopy; swine; thermal blood flow measurement

The objectives of this research are (1) to further develop and extensively apply the thermal pulse decay (TDP) method to measure the blood perfusion in various organs and tissues; (2) to evaluate the influence of various vascular architectures on the convective heat transfer in the tissue; (3) to develop and evaluate a modified version of the TPPD method (MTPD) that is based on a more detailed description of heat transfer within the tissue that accounts for the convective contribution due to blood flow. The main measurement devices will be arrays of two or three thermistor probes in various configurations. Each microprobe in such arrays will be similar to the one used by the present TPD method. Thus the MTPD method will possess all of the advantages of the TPD method resulting from the small size of the probe and the transient nature of the measurement. The results obtained from the in vivo and in vitro (fixed tissue phatoms) experiments applying the MTPD method will be compared with other of blood flow measurement (microspheres, EM blood flowmeter, etc.) and the results critically discussed, analyzed, and evaluated, based on some new theoretical models of heat transfer in living tissues proposed recently by others and by the applicants. The proposed MTPD method of measuring local tissue perfusion has application in numerous areas of cardiovascular study. Quantitative blood flow measurements can be obtained in organs or tissues which have been proven difficult to evaluate in the past, e.g., cortico-medullary junction in the kidney, intestine, skin, etc. Of additional importance, the theoretical contribution of the proposed research will provide a better understanding of the modes of heat transfer in biological tissues.

本研究的目标是(1)进一步开发和广泛应用 应用热脉冲衰减法(TDP)测量血液灌注量 在各种器官和组织中；(2)评价不同种类的 血管构筑对组织内对流换热的影响 开发和评估TPPD方法的修改版本(MTPD)，该方法 是基于对组织内热传递的更详细的描述 这就解释了血液流动对对流的贡献。 主要测量装置将是由两个或三个热敏电阻组成的阵列 各种配置的探头。这样的阵列中的每个微探针都将是 类似于目前的TPD方法所使用的方法。因此，MTPD方法 将拥有TPD方法的所有优点，这是由于 探头的小尺寸和测量的瞬变性质。 从体内和体外获得的结果(固定组织植入物) 应用MTPD方法的实验将与其他血液的实验进行比较 流量测量(微球、EM血流计等)而结果是 批判性地讨论、分析和评估，基于一些新的 最近提出的活体组织内热传递的理论模型 其他人和申请者。 提出的测量局部组织灌注量的MTPD方法具有 应用于心血管研究的多个领域。定量血液 流量测量可以在器官或组织中获得，这些器官或组织已经 过去证明难以评估，例如皮质-髓质交界处 在肾脏、肠道、皮肤等方面。 为提出的研究提供更好的理论贡献 了解生物组织中的热传递模式。