LOCAL TISSUE PERFUSION: TPD DEVELOPMENT AND MODIFICATION

本研究的目的是（1）进一步发展和广泛 应用热脉冲衰减法（TDP）测量血液灌注 在各种器官和组织中;（2）评估各种 血管结构对组织内对流传热的影响;（3） 开发和评估TPPD方法（MTPD）的修改版本， 基于对组织内热传递的更详细描述 这说明了由于血流而产生的对流作用。 主要的测量设备将是两个或三个热敏电阻阵列 各种配置的探头。 这种阵列中的每个微探针将被 类似于本TPD方法所用的方法。 MTPD方法 将拥有TPD方法的所有优点， 探头的小尺寸和测量的瞬态性质。 从体内和体外（固定组织噬菌体）获得的结果 应用MTPD方法的实验将与其他血液分析方法进行比较。 流量测量（微球、EM血液流量计等）和结果 批判性地讨论，分析和评估，基于一些新的 最近提出的活组织传热理论模型， 其他人和申请人。 所提出的测量局部组织灌注的MTPD方法具有 应用于心血管研究的许多领域。 定量血 可以在已经被移植的器官或组织中获得流量测量 过去被证明难以评估，例如，皮质-髓质连接 在肾脏、肠、皮肤等中。另外重要的是， 所提出的研究的理论贡献将提供一个更好的 了解生物组织中的热传递模式。

The objectives of this research are (1) to further develop and extensively apply the thermal pulse decay (TDP) method to measure the blood perfusion in various organs and tissues; (2) to evaluate the influence of various vascular architectures on the convective heat transfer in the tissue; (3) to develop and evaluate a modified version of the TPPD method (MTPD) that is based on a more detailed description of heat transfer within the tissue that accounts for the convective contribution due to blood flow. The main measurement devices will be arrays of two or three thermistor probes in various configurations. Each microprobe in such arrays will be similar to the one used by the present TPD method. Thus the MTPD method will possess all of the advantages of the TPD method resulting from the small size of the probe and the transient nature of the measurement. The results obtained from the in vivo and in vitro (fixed tissue phatoms) experiments applying the MTPD method will be compared with other of blood flow measurement (microspheres, EM blood flowmeter, etc.) and the results critically discussed, analyzed, and evaluated, based on some new theoretical models of heat transfer in living tissues proposed recently by others and by the applicants. The proposed MTPD method of measuring local tissue perfusion has application in numerous areas of cardiovascular study. Quantitative blood flow measurements can be obtained in organs or tissues which have been proven difficult to evaluate in the past, e.g., cortico-medullary junction in the kidney, intestine, skin, etc. Of additional importance, the theoretical contribution of the proposed research will provide a better understanding of the modes of heat transfer in biological tissues.