LONG TERM BIODEGRADATION OF ELASTOMERIC BIOMATERIALS

弹性生物材料的长期生物降解

• 批准号: 3338002
• 负责人: P ANNE HILTNER
• 金额: $ 17.95万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-12-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3338002
• 关键词: biomaterial development /preparation; biomaterial evaluation; biotransformation; cytotoxicity; elastomers; gel filtration chromatography; laboratory rat; mechanical stress; polymers; polyurethanes

The proposed research is directed toward understanding the effect of the physiological environment on the degradation of polymeric biomaterials. Accelerated in vivo and in vitro methods will be used to study biodegradation of polyurethane elastomers used in cardiovascular applications. Procedures for an accelerated in vivo biodegradation test will be developed using chemotactic peptides. Temporal variations of enzyme levels and inflammatory cells in the exudate will be correlated with observed property changes. A model poly(alpha-amino acid) elastomer will be used to gain a fundamental understanding of the enzyme degradation mechanism. Stress-enhancement is proposed as a new method of accelerated in vitro testing. This method is also relevant to many end use applications of the materials chosen for investigation.

这项拟议的研究旨在了解 生理环境对聚合物生物材料降解的影响。 将采用体内加速和体外加速的方法研究生物降解性 心血管用途的聚亚安酯弹性体。适用于 将利用趋化作用开发体内加速生物降解测试 多肽。大鼠脑组织中酶水平和炎性细胞的时间变化 渗出物将与观察到的特性变化相关联。一位模特 将使用聚(α-氨基酸)弹性体来获得基本的 了解酶的降解机理。应力增强是 提出了一种新的体外加速试验方法。这种方法也是 与选定用于调查的材料的许多最终用途相关。