LONG TERM BIODEGRADATION OF ELASTOMERIC BIOMATERIALS

弹性生物材料的长期生物降解

• 批准号: 3338004
• 负责人: P ANNE HILTNER
• 金额: $ 12.39万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-12-01 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3338004
• 关键词: biomaterials; biotransformation; cardiovascular prosthesis; chemical group; circular dichroism; conformation; crosslink; disease /disorder model; implant; mathematical model; mechanical stress; model; molecular weight; papain; peptidases; polymers; polyurethanes; radiotracer; spectrometry; stress; surface property; temperature; tissue /cell culture

The proposed research is directed toward understanding the effect of the physiological environment on the degradation of polymeric biomaterials. Accelerated in vivo and in vitro methods will be used to study biodegradation of polyurethane elastomers used in cardiovascular applications. Procedures for an accelerated in vivo biodegradation test will be developed using chemotactic peptides. Temporal variations of enzyme levels and inflammatory cells in the exudate will be correlated with observed property changes. A model poly(alpha-amino acid) elastomer will be used to gain a fundamental understanding of the enzyme degradation mechanism. Stress-enhancement is proposed as a new method of accelerated in vitro testing. This method is also relevant to many end use applications of the materials chosen for investigation.

拟议的研究旨在了解 生理环境对高分子生物材料降解的影响。 加速体内和体外方法将用于研究生物降解 用于心血管应用的聚氨酯弹性体。 程序 将使用趋化剂开发加速体内生物降解试验 肽。 酶水平和炎症细胞的时间变化 渗出物将与观察到的性质变化相关。 一个模型 聚（α-氨基酸）弹性体将用于获得基本的 了解酶的降解机制。 压力增强是 提出作为加速体外测试的新方法。 这个方法也是 与所选调查材料的许多最终用途应用相关。