Organic Supramolecular Chemistry: A Research Programme on Synthetic Molecular Motors and Machines

有机超分子化学：合成分子马达和机器的研究计划

• 批准号: EP/H021620/2
• 负责人: David Leigh
• 金额: $ 209.93万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH021620%2F2
• 关键词: Organic; Supramolecular; Chemistry; Research; Programme

Perhaps the best way to appreciate the technological potential of controlled molecular-level motion it is to recognise that nanomotors and molecular-level machines lie at the heart of every significant biological process. Over billions of years of evolution Nature has not repeatedly chosen this solution for achieving complex task performance without good reason. In stark contrast to biology, none of mankind's fantastic myriad of present day technologies exploit controlled molecular-level motion in any way at all: every catalyst, every material, every polymer, every pharmaceutical, every chemical reagent, all function exclusively through their static or equilibrium dynamic properties. When we learn how to build artificial structures that can control and exploit molecular level motion, and interface their effects directly with other molecular-level substructures and the outside world, it will potentially impact on every aspect of functional molecule and materials design. An improved understanding of physics and biology will surely follow.The Leigh group are one of the world leaders in the design and construction of artificial molecular motors and synthetic molecular machine systems. As well as having prepared some of the first synthetic motors and functional machine molecules, they have explained in chemical terms the concept of ratcheting and introduced it as a design concept for synthetic molecular motor systems. This is a fundamental tool that, once fully explored and mastered, will allow scientists to drive chemical systems away from equilibrium in a controlled manner. This research programme seeks to expand and exploit our understanding of these systems to make more advanced and more functional synthetic molecular machines, including molecular motors driven by chemical fuels, synthetic molecular structures that can 'walk' down molecular tracks, and artificial molecular machines that can act as nano-robots, synthesizing complex polymers of a particular sequence.

也许了解受控分子级运动技术潜力的最佳方法是认识到纳米电机和分子级机器是每个重要生物过程的核心。经过数十亿年的进化，大自然不会在没有充分理由的情况下反复选择这种解决方案来实现复杂的任务性能。与生物学形成鲜明对比的是，人类当今的无数技术根本没有以任何方式利用受控的分子水平运动：每种催化剂、每种材料、每种聚合物、每种药物、每种化学试剂，都完全通过其静态或平衡动态特性发挥作用。当我们学习如何构建可以控制和利用分子水平运动的人工结构，并将其效果直接与其他分子水平子结构和外界连接时，它将潜在地影响功能分子和材料设计的各个方面。对物理学和生物学的理解必将随之提高。Leigh 小组是人工分子马达和合成分子机器系统设计和建造领域的世界领先者之一。除了制备了一些第一个合成发动机和功能性机器分子外，他们还用化学术语解释了棘轮的概念，并将其作为合成分子发动机系统的设计概念引入。这是一个基本工具，一旦得到充分探索和掌握，科学家将能够以受控方式使化学系统脱离平衡。该研究项目旨在扩展和利用我们对这些系统的理解，以制造更先进、功能更强大的合成分子机器，包括由化学燃料驱动的分子马达、可以沿着分子轨道“行走”的合成分子结构，以及可以充当纳米机器人、合成特定序列的复杂聚合物的人造分子机器。

项目成果

Selecting reactions and reactants using a switchable rotaxane organocatalyst with two different active sites.

• DOI: 10.1039/c4sc03279a
• 发表时间: 2015-01-01
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Beswick J;Blanco V;De Bo G;Leigh DA;Lewandowska U;Lewandowski B;Mishiro K
• 通讯作者: Mishiro K

A Solomon link through an interwoven molecular grid.

• DOI: 10.1002/anie.201502095
• 发表时间: 2015-06-22
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Beves, Jonathon E.;Danon, Jonathan J.;Leigh, David A.;Lemonnier, Jean-Francois;Vitorica-Yrezabal, Inigo J.
• 通讯作者: Vitorica-Yrezabal, Inigo J.

The self-sorting behavior of circular helicates and molecular knots and links.

• DOI: 10.1002/anie.201404270
• 发表时间: 2014-07-21
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Ayme, Jean-Francois;Beves, Jonathon E.;Campbell, Christopher J.;Leigh, David A.
• 通讯作者: Leigh, David A.

Tetrameric cyclic double helicates as a scaffold for a molecular Solomon link.

• DOI: 10.1002/anie.201302634
• 发表时间: 2013-06-17
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Beves, Jonathon E.;Campbell, Christopher J.;Leigh, David A.;Pritchard, Robin G.
• 通讯作者: Pritchard, Robin G.