Novel biomimetic vascular biomaterials using extracellular matrix molecules

使用细胞外基质分子的新型仿生血管生物材料

• 批准号: DP150104242
• 负责人: A/Prof Jelena Rnjak-Kovacina
• 金额: $ 17.4万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-05 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104242
• 关键词: Novel; biomimetic; vascular; biomaterials; using

There is currently a pressing, unmet need for biodegradable, functional biomaterials that support endothelial cell interactions and vascular regeneration. Lack of sufficient vascular regeneration is the biggest obstacle in translating advances in biomaterials development to clinical, diagnostic and research applications. This project aims to address this need by developing novel biomaterial platforms that mimic the extracellular matrix of the vascular niche. We plan to utilise unique extracellular matrix domains and bioprinting techniques to control and guide endothelial cell functions. We could thus contribute to the knowledge base in vascular biology and bioengineering, forming the basis for vascular materials of the future.

目前对支持内皮细胞相互作用和血管再生的可生物降解的功能性生物材料存在迫切的未满足的需求。缺乏足够的血管再生是将生物材料开发进展转化为临床、诊断和研究应用的最大障碍。该项目旨在通过开发新型生物材料平台来满足这一需求，该平台模拟血管生态位的细胞外基质。我们计划利用独特的细胞外基质结构域和生物打印技术来控制和引导内皮细胞功能。因此，我们可以为血管生物学和生物工程的知识基础做出贡献，为未来的血管材料奠定基础。