CAFFEINE INFLUENCES ON EXERCISE AND PSYCHOLOGICAL STRESS

咖啡因对运动和心理压力的影响

• 批准号: 3343270
• 负责人: William R Lovallo
• 金额: $ 12.96万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3343270
• 关键词: behavioral medicine; bioenergetics; caffeine; cardiovascular disorder diagnosis; cardiovascular disorder prevention; cardiovascular function; disease /disorder proneness /risk; fatty acid metabolism; free fatty acids; glucose metabolism; human subject; hypertension; neuroendocrine system; neurotransmitters; noninvasive diagnosis; physiologic stressor; psychological stressor; stress

The systemic effects of caffeine have not been well delineated in conjunction with physical and psychological stress in humans. Either caffeine or stressor challenge alone is capable of influencing cardiovascular function, neurohormonal output, and energy mobilization. The two in combination may interact on these functions, perhaps enhancing each other's effects. The aims of this project are to study how caffeine modifies these responses to psychological and physical challenge both in healthy young men and in those at risk for the development of hypertension. The proposed research will therefore examine psychological and physical challenges in combination with moderate levels of caffeine in a pair of counterbalanced, placebo-controlled, double-blind, corssover studies on these two subject groups. Psychological challenge will be induced by having subjects work under a high state of vigilance on a very demanding mental task to attain monetary reward. Physical challenges will consist of pedalling a bicycle ergometer at each level of a graded series of workloads and isometric handgrip. Dependent variables are: Cardiovascular - heart rate, systemic blood pressures, stroke volume, cardiac output, end-systolic and end-diastolic volumes, ejection fractions, peripheral resistance, and systolic time intervals; Neuroendocrine - plasma concentrations of norepinephrine, epinerphrine, and cortisol; and Energy Mobilization - plasma free fatty acid levels and glucose. The longterm objective of this work is to establish a base of knowledge on the role caffeine may play in modifying physiological responses to stress in nromals and in persons at risk of developing cardiovascular diseases such as hypertension. Such information would be useful in determining whether reduction in caffeine use has any potential in disease prevention either for the population as a whole or for certain targeted groups such as borderline hypertensives.

咖啡因对全身的影响还没有很好的描述