MECHANISMS OF VERAPAMIL INHIBITION OF BRONCHOSPASM
维拉帕米抑制支气管痉挛的机制
基本信息
- 批准号:3343525
- 负责人:
- 金额:$ 6.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1984
- 资助国家:美国
- 起止时间:1984-04-01 至 1987-03-31
- 项目状态:已结题
- 来源:
- 关键词:aerosols allergens antiadrenergic agents antiallergic agents antihistamines asthma bronchospasm disease /disorder model drug interactions drug metabolism helminthic antigen high performance liquid chromatography nerve endings neural transmission neuropharmacology parasympathetic nervous system pentobarbital reflex respiratory airway pressure respiratory muscles verapamil
项目摘要
We have demonstrated verapamil's ability to abolish antigen-induced
bronchospasm. In contrast, verapamil was effective in only attenuating the
maximal increase in airway resistance induced by histamine. These findings
have important implications concerning the mechanism of action of
verapamil, suggesting major action at a site other than airway smooth
muscle.
The overall goal of this project is to determine the major mode of action
of verapamil as it affects bronchoconstriction in a canine asthma model.
The first aim of this study will be to determine if verapamil can inhibit
the release of hisamine and perhaps other mediators of immediate
hypersensitivity. Arterial blood samples will be collected during Ascaris
suum antigen (ASA) aerosol challenges of allergic dogs before and after
verapamil treatment. Serum histamine levels will be determined by high
pressure liquid chromatography and/or by chemical assay.
The second aim will be to determine if vagal reflexes play a major role in
our model of allergic bronchoconstriction. Bilateral vagal blockade will
be produced during ASA and histamine bronchoprovocation. In addition, the
effects of pentobarbital anesthesia will be examined by conducting control
experiments in which chloralose is utilized as the primary anesthetic agent.
The third aim will be a test of the hypothesis that verapamil can inhibit
acetylcholine release from parasympathetic ganglia and nerve endings within
the airway smooth muscle. Frequency/response measurements will be made
during electrical field stimulation of trachealis muscle strips in vitro in
the presence and absence of verapamil.
我们已经证明维拉帕米能够消除抗原诱导
项目成果
期刊论文数量(0)
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GILBERT A RINARD其他文献
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{{ truncateString('GILBERT A RINARD', 18)}}的其他基金
MECHANISMS OF VERAPAMIL INHIBITION OF BRONCHOSPASM
维拉帕米抑制支气管痉挛的机制
- 批准号:
3343526 - 财政年份:1984
- 资助金额:
$ 6.23万 - 项目类别:
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