CORONARY ARTERY VASOMOTOR ACTIVITY

这些研究的目的是描述相互关系 血管活性、血管损伤和血栓形成之间的关系， 心外膜冠状动脉 研究将长期进行， 使用超声尺寸晶体监测血管扩张的仪器狗 活动 将研究以下具体假设。 1. 内源性和外源性肾上腺素能刺激作用，α肾上腺素能 心外膜冠状动脉的收缩和β肾上腺素能松弛 在清醒犬中;在正常冠状动脉中的主要效应 是β肾上腺素能松弛 2. 内源性和外源性血管活性物质 化合物显著影响正常人的血管收缩/血管舒张 清醒狗的心外膜动脉 3. 正常内皮细胞 调节基础血管活性和对内源性和 外源性肾上腺素能刺激和内源性和外源性血管活性 化合物;内皮剥脱将改变基础血管活性， 这些反应中的一些。 4. 局部内皮损伤， 进行性血栓形成释放血管活性化合物， 心外膜和壁内脉管系统的局部血管收缩。 5. 局部内皮损伤和进行性血栓形成改变了反应 对内源性和外源性肾上腺素能刺激的反应以及对 内源性和外源性血管活性化合物。 6. 冠状 在存在部分血管闭塞效应时的血管收缩 血小板聚集和进行性血栓形成。 这些研究涉及 这些问题对于理解临床 冠状动脉痉挛血栓心肌缺血综合征 和梗塞。

The objectives of these studies are to characterize the interrelationship between vasomotor activity, vascular injury and thrombosis in the epicardial coronary arteries. Studies will be performed in chronically instrumented dogs using ultrasonic dimension crystals to monitor vasomotor activity. The following specific hypotheses will be studied. 1. Endogenous and exongenous adrenergic stimulation effects, Alpha adrenergic constriction and Beta adrenergic relaxation in epicardial coronary arteries in the conscious dog; the predominant effect in the normal coronary artery is Beta adrenergic relaxation. 2. Endogenous and exogenous vasoactive compounds effect significant vasoconstriction/vasodilation of normal epicardial arteries in the conscious dog. 3. The normal endothelium modulates basal vasomotor activity and the responses to endogenous and exogenous adrenergic stimulation and endogenous and exogenous vasoactive compounds; endothelial denudation will alter basal vasomotor activity and certain of these responses. 4. Localized endothelial injury and progressive thrombosis releases vasoactive compounds that produce local and regional vasoconstriction of the epicardial and intramural vasculature. 5. Local endothelial injury and progressive thrombosis alters the response to endogenous and exogenous adrenergic stimulation and the response to endogenous and exogenous vasoactive compounds. 6. Coronary vasoconstriction in the presence of partial vessel occlusion effects platelet aggregation and progressive thrombosis. These studies address questions that are fundamental to the understanding of the clinical syndrome of coronary artery spasm and thrombosis and myocardial ischemia and infarction.