课题基金 / 基金详情

Bio-Active Polymer Driven Cell Based Systems - Predicting Human Drug Toxicity

Bio-Active Polymer Driven Cell Based Systems - Predicting Human Drug Toxicity
生物活性聚合物驱动的细胞系统 - 预测人类药物毒性
批准号:
EP/H029680/1
负责人:
Mark Bradley
金额:
$25.54万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2010
资助国家:
英国
项目状态:
已结题
起止时间:
2010 至 --

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中文摘要
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英文摘要
We are all very familiar with polymers of one type or another, playing as they do a vital role in essentially all aspects of our lives, from fabrics to pens and plastic bags to car components polymers play a vital role in all aspects of our lives. Polymers also have a huge medicinal potential. This can range from the passive (e.g. blood bags and catheters) to the invasive with stents, dissolvable stitches and polymeric based drug release systems all playing a role in modern healthcare.We have identified and patented a polymer family that allow liver cells to grow with full function and for long periods of time. This is important because liver cells are notoriously difficult to maintain and grow, yet are vitally important in drug screening. Using our polymers we can therefore grow up liver cells and use then to assess drug toxicity and the potentially toxic metabolic products of liver breakdown.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
A SIMPLE POLYURETHANE MATRIX PROMOTES HEPATIC ENDODERM VIABILITY AND INDUCIBLE DRUG METABOLISM: IMPLICATIONS FOR DRUG TOXICOLOGY TESTING AND THE DESIG
简单的聚氨酯基质促进肝内胚层活力和诱导药物代谢:对药物毒理学测试和设计的影响
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Claire P Medine]
通讯作者: Claire P Medine
844 POLYMER LIBRARY SCREENING IDENTIFIES AN EXTRACELLULAR MATRIX THAT PROMOTES AND STABILISES HUMAN EMBRYONIC STEM CELL-DERIVED HEPATOCYTE FUNCTION
844 聚合物库筛选鉴定出促进和稳定人胚胎干细胞衍生的肝细胞功能的细胞外基质
DOI: 10.1016/s0168-8278(09)60846-1
发表时间: 2009
期刊: Journal of Hepatology
影响因子: 25.7
作者: [Hay D]
通讯作者: Hay D
Lighting the Way to a Healthy Nation - Optical 'X-rays' for Walk Through Diagnosis & Therapy
  • 批准号:
    EP/T020997/2
  • 项目类别:
    Research Grant
  • 资助金额:
    $362.86万
  • 财政年份:
    2023
  • 负责人:
    Mark Bradley
  • 依托单位:
Lighting the Way to a Healthy Nation - Optical 'X-rays' for Walk Through Diagnosis & Therapy
  • 批准号:
    EP/T020997/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $710.72万
  • 财政年份:
    2020
  • 负责人:
    Mark Bradley
  • 依托单位:
EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond
  • 批准号:
    EP/R005257/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $490.95万
  • 财政年份:
    2019
  • 负责人:
    Mark Bradley
  • 依托单位:
Smart materials for targeted stem cell fate and function in skeletal repair
  • 批准号:
    BB/L008637/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $38.13万
  • 财政年份:
    2014
  • 负责人:
    Mark Bradley
  • 依托单位:
国内基金
海外基金
光-电驱动下的AIE-active手性高分子CPL液晶器件研究
  • 批准号:
    92156014
  • 项目类别:
    重大研究计划
  • 资助金额:
    70.0万元
  • 批准年份:
    2021
  • 负责人:
    成义祥
  • 依托单位:
光-电驱动下的AIE-active手性高分子CPL液晶器件研究
  • 批准号:
    --
  • 项目类别:
    --
  • 资助金额:
    70万元
  • 批准年份:
    2021
  • 负责人:
    成义祥
  • 依托单位: