Bio-Active Polymer Driven Cell Based Systems - Predicting Human Drug Toxicity

生物活性聚合物驱动的细胞系统 - 预测人类药物毒性

• 批准号: EP/H029680/1
• 负责人: Mark Bradley
• 金额: $ 25.54万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH029680%2F1
• 关键词: Bio; Active; Polymer; Driven; Cell

We are all very familiar with polymers of one type or another, playing as they do a vital role in essentially all aspects of our lives, from fabrics to pens and plastic bags to car components polymers play a vital role in all aspects of our lives. Polymers also have a huge medicinal potential. This can range from the passive (e.g. blood bags and catheters) to the invasive with stents, dissolvable stitches and polymeric based drug release systems all playing a role in modern healthcare.We have identified and patented a polymer family that allow liver cells to grow with full function and for long periods of time. This is important because liver cells are notoriously difficult to maintain and grow, yet are vitally important in drug screening. Using our polymers we can therefore grow up liver cells and use then to assess drug toxicity and the potentially toxic metabolic products of liver breakdown.

我们都非常熟悉这种或那种类型的聚合物，因为它们在我们生活的各个方面都发挥着至关重要的作用，从织物到钢笔和塑料袋到汽车部件聚合物在我们生活的各个方面都发挥着至关重要的作用。聚合物还具有巨大的药用潜力。这可以从被动的（例如血袋和导管）到侵入性的支架，可溶解的缝线和聚合物基药物释放系统，所有这些都在现代医疗保健中发挥作用。我们已经确定并申请了一个聚合物系列，使肝细胞能够长时间长时间地全功能生长。这一点很重要，因为众所周知，肝细胞很难维持和生长，但在药物筛选中至关重要。因此，使用我们的聚合物，我们可以培养肝细胞，然后使用它来评估药物毒性和肝脏分解的潜在毒性代谢产物。

项目成果

A SIMPLE POLYURETHANE MATRIX PROMOTES HEPATIC ENDODERM VIABILITY AND INDUCIBLE DRUG METABOLISM: IMPLICATIONS FOR DRUG TOXICOLOGY TESTING AND THE DESIG

简单的聚氨酯基质促进肝内胚层活力和诱导药物代谢：对药物毒理学测试和设计的影响

• 发表时间: 2009
• 作者: Claire P Medine

844 POLYMER LIBRARY SCREENING IDENTIFIES AN EXTRACELLULAR MATRIX THAT PROMOTES AND STABILISES HUMAN EMBRYONIC STEM CELL-DERIVED HEPATOCYTE FUNCTION

844 聚合物库筛选鉴定出促进和稳定人胚胎干细胞衍生的肝细胞功能的细胞外基质

• DOI: 10.1016/s0168-8278(09)60846-1
• 发表时间: 2009
• 期刊: Journal of Hepatology
• 影响因子: 25.7
• 作者: Hay D