TREATMENT OF MILD HYPERTENSION STUDY (TOMHS)

轻度高血压的治疗研究 (TOMHS)

• 批准号: 3348072
• 负责人: Richard Hugo Grimm
• 金额: $ 96.16万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1993-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3348072
• 关键词: ACE inhibitors; alcoholic beverage consumption; alpha antiadrenergic agent; antihypertensive agents; behavior modification; beta antiadrenergic agent; blood chemistry; blood pressure; calcium channel blockers; cardiovascular disorder chemotherapy; cardiovascular disorder prevention; clinical trials; diuretics; drug adverse effect; echocardiography; electrocardiography; enalapril; exercise; heart dimension /size; human middle age (35-64); human subject; hypertension; low salt diet; myocardial ischemia /hypoxia; nutrition related tag; questionnaires; statistics /biometry; therapy compliance; urinalysis; weight control

This proposal is for the renewal for Phase I of the Treatment of "Mild" Hypertension Study (T0MHS). The study will allow for long-term detailed assessment of 902 hypertensives prescribed one of five active drugs (representing major classes of medications currently in use) or placebo, using a randomized double-blind design. Each treatment group also is advised nonpharmacologic methods to control their blood pressure including weight loss, dietary sodium reduction, alcohol reduction and increased leisure-time physical activity. This proposal is for a 2 year and 7 month continuation which includes 2 additional years of follow-up and a final 7 months for close-out activities, data analysis and publications.

本建议是为第一阶段治疗“轻度” 高血压研究（T0MHS）。 这项研究将允许长期详细的 评估902名高血压患者处方的五种活性药物之一 （代表目前使用的主要药物类别）或安慰剂， 采用随机双盲设计。 每个治疗组也是 建议采用非药物方法控制血压，包括 体重减轻，饮食钠减少，酒精减少和增加 休闲时间的体育活动。 本提案为期2年零7个月 持续，包括额外2年的随访和最终7年的随访 用于收尾活动、数据分析和出版物的时间。

项目成果

Chlorthalidone attenuates the reduction in total cholesterol and small, dense LDL cholesterol subclass associated with weight loss.

氯噻酮可减弱与减肥相关的总胆固醇和小而密的低密度脂蛋白胆固醇亚类的减少。

• DOI: 10.1093/ajh/6.7.636
• 发表时间: 1993
• 期刊: American journal of hypertension
• 影响因子: 3.2
• 作者: Bradley,K;Flack,JM;Belcher,J;Elmer,P;Miller,P;GrimmJr,R
• 通讯作者: GrimmJr,R

Efficacy and tolerance of antihypertensive treatment in men and women with stage 1 diastolic hypertension. Results of the Treatment of Mild Hypertension Study.

患有 1 期舒张期高血压的男性和女性抗高血压治疗的疗效和耐受性。

• 发表时间: 1996
• 期刊: Archives of internal medicine.
• 作者: Lewis,CE;Grandits,A;Flack,J;McDonald,R;Elmer,PJ
• 通讯作者: Elmer,PJ

The treatment of mild hypertension study. A randomized, placebo-controlled trial of a nutritional-hygienic regimen along with various drug monotherapies. The Treatment of Mild Hypertension Research Group.

轻度高血压的治疗研究。

• DOI: 10.1001/archinte.151.7.1413
• 发表时间: 1991
• 期刊: Archives of internal medicine

The effects of sodium reduction on control of blood pressure elevation: a review.

减少钠摄入量对控制血压升高的影响：综述。

• 发表时间: 1987
• 期刊: Bibliotheca cardiologica
• 作者: Grimm,RH;Prineas,RJ
• 通讯作者: Prineas,RJ

Long-term effects on plasma lipids of diet and drugs to treat hypertension. Treatment of Mild Hypertension Study (TOMHS) Research Group.

饮食和治疗高血压的药物对血脂的长期影响。

• DOI: 10.1001/jama.1996.03530440029033
• 发表时间: 1996
• 期刊: JAMA
• 作者: GrimmJr,RH;Flack,JM;Grandits,GA;Elmer,PJ;Neaton,JD;Cutler,JA;Lewis,C;McDonald,R;Schoenberger,J;Stamler,J
• 通讯作者: Stamler,J