ANTIHYPERTENSIVE DRUGS: BIOBEHAVIORAL EFFECTS

抗高血压药物：生物行为效应

• 批准号: 3346566
• 负责人: JAYLAN S TURKKAN
• 金额: $ 15.09万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3346566
• 关键词: angiotensin /renin /aldosterone hypertension; antihypertensive agents; auditory discrimination; auditory threshold; behavior test; beta antiadrenergic agent; calcium channel blockers; captopril; centrally acting drug; discrimination learning; disease /disorder model; diuretics; drug adverse effect; memory; psychomotor reaction time; psychopharmacology; psychophysics; visual threshold

The present proposal will investigate the effects of antihypertensive drugs on sensory function, motor ability, learning and memory in baboons both when they are normotensive, and after an experimental hypertensive state has been induced. Clinical case reports of adverse behavioral side-effects of antihypertensive compounds have been frequent, leading many patients to discontinue medication. Unfortunately, both human and animal investigations have been equivocal as to the behavioral performance and sensory effects of frequently used drugs such as beta-blockers, and centrally acting antihypertensive compounds. Detailed information is lacking on the behavioral and sensory effects of diuretics, and on the newer antihypertensive compounds such as angiotensin-converting-enzyme inhibitors and calcium-channel blockers. The proposed project will use two baboon models of hypertension, a deoxycorticosterone acetate (DOCA)-salt model and a Goldblatt (two-kidney, one-clamp) model, to simulate low renin and high renin states of hypertension, respectively. The effects of five different classes of antihypertensive compounds will be examined in these two models with continuous blood pressure monitoring via implanted arterial catheters. Detailed assessments of both behavioral and central nervous system effects of these antihypertensive agents will be provided by having animals perform tasks designed to assess sensory and motor function as well as specific aspects of conditional learning and memory.

本提案将研究降压药的影响 关于狒狒的感觉功能，运动能力，学习和记忆 当它们正常时，并且在实验性高血压状态之后 已被诱导。 不利行为副作用的临床病例报告 降压化合物的经常经常，导致许多患者进入 停止药物。 不幸的是，人类和动物都 关于行为绩效和 经常使用的药物（例如β受体阻滞剂）的感觉效应， 中央作用的降压化合物。 详细信息是 缺乏利尿剂的行为和感觉效应，以及 较新的降压化合物，例如血管紧张素转换 - 酶 抑制剂和钙通道阻滞剂。 拟议的项目将使用两个 高血压的狒狒模型，一种乙酸乙酸乙酸甘发（DOCA）-SALT 模型和Goldblatt（两凯尼，一钳）模型，以模拟低肾素 分别是高血压的高肾素状态。 五个 在这些中将检查不同类别的降压化合物 通过植入动脉进行连续血压监测的两个模型 导管。 行为和中枢神经的详细评估 这些降压药的系统效应将通过拥有 动物执行旨在评估感觉和运动功能的任务 作为条件学习和记忆的特定方面。