权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

ASSESSMENT OF LUNG FUNCTION AND GROWTH IN YOUNG CHILDREN

幼儿肺功能和生长的评估

基本信息

批准号：
3344530
负责人：
MICHAEL A WALL
金额：
$ 4.54万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
起止时间：
1984-07-01 至 1986-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3344530
关键词：
alpha 1 antitrypsin deficiency asthma breath tests computer assisted diagnosis cystic fibrosis disease /disorder proneness /risk gender difference growth /development human subject longitudinal human study lung mathematical model online computer preschool child (1-5) respiratory airway volume respiratory disorder diagnosis respiratory function respiratory infections

项目摘要

At present there is no methodology available for assessing lung function and growth in young children that is painless, non-threatening, fast and at the same time is sensitive to early abnormalities in airways function or ventilization inhomogeneity. Thus at present our knowledge of patterns of lung growth and functions as they relate to age, sex, size, and lung disease is scanty. Similarly, we do not have the methods or basic information required to assess risk factors in young children for the possible development of chronic lung disease such as passive smoking or viral respiratory tract infections. One of the priorities of the 1983 NIH Workshop On Passive Smoking was the development of such methods. The objectives of this proposal are: 1) to develop a methodology appropriate for assessing lung growth and function in young children; (2) to determine the precision, specifically, and variability of the method and to develop reference standards for young children; (3) to test the hypothesis that the method to be used has the sensitivity required to separate out "healthy" from "non-healthy;" (4) to test the hypothesis that lung growth is diffferent in boys and girls; (5) to test the hypothesis that ventilation homogeneity changes with age; and (6) to use the methodoligy which is developed in a long-term collaboarative study of the natural history of alpha1 antitrypsin defidiency. The method to be used is on-line computerized moment analysis of multibreath nitrogen washout (MBNW). The technique requires only that the subject quietly breathe oxygen for less than 2 minutes, and the analysis of the curve is independent of body size, lung size, tidal volume, or respiratory rate. The data obtained from the curve include functional residual capacity, moments 0, 1 and 2 of the MBNW curve, moment ratios, lung clearance index, and other indices of the washout. The required software has been developed and preliminary data has been obtained from 36 healthy children ages 2-6 years, 10 children with cystic fibrosis of the same age, and 5 young healthy adults. The data to date indicate that moment analysis of MBNW curves has the ability to fulfill the objectives of the proposal. The long-range plans are to use the information obtained from this study in long-term studies of risk factors for the development of chronic lung disease. The beginnings of one such study, a long-term collaborative description of the natural history of alpha1 antitrypsin deficiency, is included as part of the grant proposal.

目前还没有一种方法可用于评估肺功能和成长的幼儿是无痛，无威胁，快速，同时对气道功能的早期异常敏感，风成不均匀性目前，我们的知识，与年龄、性别、大小和肺相关的肺生长和功能疾病很少。同样，我们没有方法或基本的评估幼儿中的风险因素所需的信息，可能出现慢性肺病，如被动吸烟，或病毒性呼吸道感染 1983年国家卫生研究院的优先事项之一被动吸烟研讨会就是这种方法的发展。的这项建议的目标是：1）制定一种适当的方法，用于评估幼儿的肺生长和功能;（2）确定方法的精密度、特异性和变异性，并开发幼儿的参考标准;（3）检验假设，所使用的方法具有分离出“健康” 从“非健康”;（4）测试肺生长是不同的男孩和女孩;（5）以检验假设，通风同质性随年龄变化;（6）使用的方法，在长期的自然历史研究中发展起来的 α 1抗胰蛋白酶缺乏。采用的方法是在线计算机化的力矩分析，多呼吸氮洗（MBNW）。该技术只需要受试者安静地呼吸氧气少于2分钟，该曲线与身体大小、肺部大小、潮气量或呼吸频率从曲线获得的数据包括函数剩余承载力，MBNW曲线的0、1和2阶矩，矩比，肺清除指数和其他清除指数。所需的已开发了软件，并从36个国家获得了初步数据。 2-6岁的健康儿童，10名患有囊性纤维化的儿童，年龄相同，5个年轻健康的成年人。迄今为止的数据表明， MBNW曲线的矩分析能够实现以下目标：这个提议长期计划是利用从这项研究中获得的信息，慢性肺疾病危险因素的长期研究疾病一项这样的研究的开始，一项长期的合作，描述了α 1抗胰蛋白酶缺乏症的自然史，作为赠款提案的一部分。