Research Workshop on Mathematical Virology

数学病毒学研究研讨会

• 批准号: EP/H048979/1
• 负责人: Reidun Twarock
• 金额: $ 3.05万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH048979%2F1
• 关键词: Research; Workshop; Mathematical; Virology

Viruses pose a significant threat for the public health sector and new efficient anti-viral treatments are urgently required. Insights in the structures of viruses and the mechanism underlying their formation provide the basis for the development of such therapeutics. Most viruses package their genomic material in a protein container that acts as a Trojan horse, providing protection and transport for the viral genome between hosts. These protein containers are known to be well ordered, and can therefore be understood in terms of the mathematical language of symmetry. In this workshop we explore the mathematical tools necessary to understand the structures of viruses, and then exploit these results to gain insights in how viruses form and how they infect their hosts. An understanding of how these processes depend on the geometries of the protein containers potentially permits the development of novel strategies for inhibiting these processes. These in turn have the potential to result in the development of anti-viral drugs targeted at such stages of the viral life cycle. In this interdisciplinary workshop we are planning to bring together mathematicians with biophysicists, computational and experimental biologists working on various aspects of the structure and assembly of viruses, thus creating an environment that facilitates meaningful interactions for the mathematical community with other relevant disciplines. Such interactions are especially important to ensure the impact of the mathematical modelling in biology. In this workshop we will explore opportunities for mathematical modelling in the areas of virus structure, assembly, genome packaging and, for the first time, also in nanotechnology applications. These focus areas will be represented by keynote talks as well as hot topic debates at the meeting. Earmarked bursaries will encourage young researchers to attend the meeting.

病毒对公共卫生部门构成重大威胁，迫切需要新的有效抗病毒治疗方法。对病毒结构及其形成机制的深入了解为此类疗法的开发提供了基础。大多数病毒将其基因组材料包装在充当特洛伊木马的蛋白质容器中，为宿主之间的病毒基因组提供保护和运输。已知这些蛋白质容器是有序的，因此可以用对称的数学语言来理解。在本次研讨会中，我们探索了解病毒结构所需的数学工具，然后利用这些结果来深入了解病毒如何形成以及如何感染宿主。了解这些过程如何依赖于蛋白质容器的几何形状可能有助于开发抑制这些过程的新策略。这些反过来有可能导致针对病毒生命周期这些阶段的抗病毒药物的开发。在这个跨学科研讨会上，我们计划将数学家与生物物理学家、计算和实验生物学家聚集在一起，研究病毒结构和组装的各个方面，从而创造一个促进数学界与其他相关学科进行有意义互动的环境。这种相互作用对于确保数学模型在生物学中的影响尤其重要。在本次研讨会上，我们将探索病毒结构、组装、基因组包装领域的数学建模机会，并首次探索纳米技术应用领域的数学建模机会。这些重点领域将通过会议上的主题演讲和热点辩论来体现。专项助学金将鼓励年轻研究人员参加会议。